Sidney Kimmel Comprehensive Cancer Center At Thomas Jefferson University

This study tested a two-step, lower-intensity stem cell transplant for patients with high-risk blood cancers like leukemia and lymphoma. The goal was to control the cancer by first using low-dose chemotherapy and radiation to prepare the body, then infusing donor stem cells to at…

This study tested whether combining two drugs, sirolimus and azacitidine, could help control high-risk myelodysplastic syndrome (MDS) or acute myeloid leukemia (AML) in adults. The trial enrolled 57 patients whose cancer had returned or who could not tolerate standard high-dose c…

This small pilot study tested a new maskless device designed to keep patients' heads perfectly still during radiation therapy for head and neck cancers or brain tumors. Researchers compared the new device to the standard plastic mask to see if it was just as accurate at preventin…

This study tested a two-step stem cell transplant method for patients with high-risk blood cancers like leukemia and lymphoma. It used a drug called cyclophosphamide before the transplant to help prevent a dangerous complication called graft-versus-host disease. The goal was to i…

This small, early-stage study tested a new approach for people whose head and neck cancer has come back and can be removed with surgery. During the operation, doctors placed tiny, permanent radioactive seeds (cesium-131) into the area where the tumor was. The goal was to see if t…

This study tested whether patients with multiple myeloma or non-Hodgkin lymphoma could recover just as quickly after a stem cell transplant without receiving a standard recovery-boosting drug (G-CSF). The main goal was to see if skipping this drug led to a similar time until pati…

This study tested if giving the drug cyclophosphamide *after* a stem cell transplant, instead of before, could make transplants safer and more effective for people with blood cancers. It focused on patients who needed a transplant but did not have a perfectly matched sibling dono…

This study tested a modified two-step stem cell transplant for adults with high-risk blood cancers. Doctors used radiation and chemotherapy to wipe out the patient's diseased bone marrow and immune system, then gave donor stem cells to rebuild it. The goal was to strengthen the n…

This early study tested a new approach for men whose prostate cancer returned after previous radiation treatment. Doctors combined a short, high-dose radiation treatment with immediately heating the tumor, hoping the heat would make the cancer cells more sensitive to the radiatio…

This study tested whether the drug nivolumab could prevent melanoma from returning after surgery in patients with high-risk stage IIB or IIC skin cancer. The trial involved 26 patients who received the drug after their tumors were surgically removed. Researchers measured how long…

This small, completed study tested whether taking a daily vitamin B6 supplement could reduce hot flashes in men with prostate cancer who were receiving hormone therapy. Forty-three participants took vitamin B6 daily for 12 weeks. The goal was to see if this common, over-the-count…