Sidney Kimmel Comprehensive Cancer Center At Thomas Jefferson University

This study tested whether giving a drug called cyclophosphamide after a stem cell transplant could help the donor cells settle in better and reduce serious side effects like graft-versus-host disease (GVHD). It involved 78 people with blood cancers who received stem cells from a …

This early study tested whether adding heat therapy (hyperthermia) to high-dose radiation is safe for men whose prostate cancer returned after previous radiation. Only 3 men took part, and the main goal was to see side effects. The approach aims to make cancer cells more sensitiv…

This study tested whether the immunotherapy drug nivolumab can help prevent melanoma from coming back after surgery. It included 26 people with stage IIB or IIC melanoma that had been completely removed. The main goal was to see how long patients stayed cancer-free after treatmen…

This study tested a new approach for people whose head and neck cancer has come back. During surgery to remove the tumor, doctors placed tiny radioactive seeds (Cesium-131) directly into the area to kill any remaining cancer cells. The goal was to see if this internal radiation c…

This study tested a two-step stem cell transplant for people with blood cancers like leukemia and lymphoma. The approach uses chemotherapy and radiation before donor stem cells are given, followed by drugs to prevent graft-versus-host disease. The goal was to control the cancer a…

This study tested a two-step donor stem cell transplant in 51 people with high-risk blood cancers. The approach uses radiation and chemo before the transplant to prepare the body, then donor stem cells to rebuild healthy blood and attack remaining cancer. The goal was to improve …

This study looked at 77 people with multiple myeloma or non-Hodgkin lymphoma who had a stem cell transplant. Half got a drug called tbo-filgrastim (a growth factor) after transplant, and half did not. The goal was to see if skipping the drug still allowed patients to leave the ho…

This study tested two drugs, azacitidine and sirolimus, in 57 adults with high-risk myelodysplastic syndrome (MDS) or acute myeloid leukemia (AML) that returned or didn't respond to standard treatment. The goal was to see if the combination could shrink or control the cancer. Res…

This study tested a two-step stem cell transplant for 62 people with high-risk blood cancers like leukemia and lymphoma. First, patients got low-dose chemotherapy and radiation to prepare the body. Then, they received donor immune cells followed by a stem cell transplant. The goa…

This study tested a two-step stem cell transplant using a drug called cyclophosphamide to lower the risk of graft-versus-host disease (GVHD) in people with high-risk blood cancers like leukemia and lymphoma. 47 patients received a transplant from a matched sibling donor. The goal…

This pilot study tested a maskless immobilization device for 12 adults with head/neck cancer or brain tumors undergoing radiation therapy. The device aims to keep the head still as accurately as the standard tight plastic mask, but without the discomfort. Researchers measured how…

This pilot study tested whether vitamin B6 supplements can reduce hot flashes in 43 men with prostate cancer who were receiving hormone therapy (ADT). Hot flashes are a common side effect of this treatment. The study measured how bothersome hot flashes were before and after 8 and…

This study tested whether an educational program in high-risk neighborhoods could increase men's knowledge about prostate cancer and screening. 239 men who lived in these areas took part. The goal was to help them make informed decisions and reduce anxiety about screening.