New drug combo could make blood cancer transplants safer and more available
NCT ID NCT01349101
First seen Jun 27, 2026 · Last updated Jun 27, 2026
Summary
This study tested whether giving the drug cyclophosphamide after a stem cell transplant could help prevent a serious complication called graft-versus-host disease (GVHD) in 78 blood cancer patients. The approach aimed to make transplants from less-than-perfect donors as safe and effective as those from matched donors. The trial measured successful engraftment and GVHD rates within 100 days after transplant.
What this could mean
Our plain-language read of the trial. This is informational only — not medical advice or a prediction.
- Active substance
- cyclophosphamide
- What this could lead to
- If successful, this approach could make stem cell transplants safer and more available for blood cancer patients, especially those without a perfectly matched donor.
- What could go wrong
- This is a small, completed phase 2 trial with 78 participants. Results may not apply to all patients, and the treatment still carries risks like infection and graft-versus-host disease.
This is an AI summary of the original study and may miss details. Read our disclaimer.
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
Locations
-
Thomas Jefferson University
Philadelphia, Pennsylvania, 19107, United States
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