Sidney Kimmel Comprehensive Cancer Center At Thomas Jefferson University

This study tested a combination of precise radiation therapy and an eye injection drug (aflibercept) for people with uveal melanoma, a rare eye cancer. The goal was to see if this approach could control the tumor while reducing damage to healthy eye tissue. Only 3 people enrolled…

This study tested giving nivolumab (an immunotherapy) along with chemotherapy before surgery for early-stage non-small cell lung cancer. The goal was to see if this combination could shrink tumors more effectively before removal. The trial was terminated early and enrolled only 1…

This study looked at adding a drug called ribociclib to standard hormone therapy (enzalutamide) for men with advanced prostate cancer that had spread and stopped responding to hormone treatment. The goal was to find a safe dose and see if the combination could lower PSA levels. T…

This study tested whether combining metformin (a diabetes drug) with doxycycline (an antibiotic) could help treat localized breast or uterine cancer. It involved 29 adults who were scheduled for surgery. The goal was to see if the drugs could change certain markers in the tumor's…

This study tested whether metformin (a diabetes drug) and doxycycline (an antibiotic) could help treat head and neck cancer when taken before surgery. Only 7 people enrolled before the study was stopped early. The main goal was to see changes in cancer-related proteins, not to cu…

This small pilot study looked at whether metformin, a common diabetes medicine, could reduce side effects like dry mouth and taste changes caused by radioactive iodine treatment in people with thyroid cancer. The study planned to enroll 13 participants but was terminated early. T…