Sidney Kimmel Comprehensive Cancer Center At Thomas Jefferson University

This phase 2 trial tested whether combining metformin (a diabetes drug) with doxycycline (an antibiotic) could help treat localized breast and uterine cancers. The study enrolled 29 people who were scheduled for surgery. Researchers looked at changes in certain proteins in the tu…

This study looked at adding ribociclib to the standard hormone therapy enzalutamide for men with a certain type of advanced prostate cancer that had spread and no longer responded to hormone therapy alone. The goal was to find the best dose and see if the combination could lower …

This study tested giving the immunotherapy drug nivolumab along with chemotherapy before surgery for people with early-stage non-small cell lung cancer (stages I to IIIA). The goal was to see if this combination could shrink tumors enough to leave less than 10% cancer cells in th…

This study tested whether metformin (a diabetes drug) and doxycycline (an antibiotic) could help treat head and neck cancer when taken before surgery. The trial aimed to see if these drugs could change certain proteins in the tumor's supportive tissue. Only 7 people took part bef…

This phase II trial tested a combination of precise radiation therapy followed by injections of aflibercept (Eylea) in people with uveal melanoma, a rare eye cancer. The goal was to see if this approach could control the tumor while reducing side effects like swelling or damage t…

This small pilot study tested whether metformin, a common diabetes drug, could reduce side effects like dry mouth and taste changes from radioactive iodine treatment in people with thyroid cancer. Only 13 people took part, and the study was stopped early. The goal was to see if m…