Philogen S.p.a.

This phase 2 trial tests three experimental drugs—L19IL2, L19TNF, or a combination—injected directly into skin tumors for people with advanced basal cell carcinoma who cannot have surgery or radiation. About 180 participants will receive weekly injections for four weeks and be fo…

This early-stage study is testing a new drug, [177Lu]Lu-OncoFAP-23, alone or with another drug (L19-IL2), in people with advanced solid tumors that have a protein called FAP. The main goal is to see if the treatment is safe and to find the best dose. About 56 adults whose cancer …

This early-stage trial is testing a new drug called IL12-L19L19 (Dodekin) in 80 adults with advanced or metastatic solid tumors that have stopped responding to standard immunotherapy. The drug combines an antibody with an immune-boosting protein to target and attack cancer cells.…

This Phase 3 trial tests whether injecting Daromun directly into melanoma tumors before surgery can help prevent the cancer from returning. About 186 people with stage IIIB/C/D melanoma will either get Daromun injections plus standard surgery and follow-up therapy, or just surger…

This early-stage study tests a new radioactive imaging agent called 68Ga-OncoACP3 in 20 men with prostate cancer. The goal is to see if it is safe and can help detect cancer that has spread or come back. Participants receive one injection and then undergo PET scans to measure rad…

This early-stage study tests a new drug called F8IL10, given as an injection directly into the joint, for people with rheumatoid arthritis. The main goal is to find a safe dose and see if it helps reduce joint pain and swelling. About 42 adults with active arthritis in a knee, an…