Experimental shot before surgery may keep melanoma from coming back

NCT ID NCT03567889

Recruiting now Disease control Sponsor: Philogen S.p.A. Source: ClinicalTrials.gov ↗

First seen Jun 25, 2026 · Last updated Jun 27, 2026 · Updated 1 time

Summary

This Phase 3 trial tests whether injecting Daromun directly into melanoma tumors before surgery can help prevent the cancer from returning. About 186 people with stage IIIB/C/D melanoma will either get Daromun injections plus standard surgery and follow-up therapy, or just surgery and follow-up therapy. The main goal is to see if the Daromun group has a longer time without the cancer coming back.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: Daromun (a combination of two immune-targeting proteins, L19IL2 and L19TNF)
What this could lead to: If successful, this approach could reduce the chance of melanoma returning after surgery, offering a new treatment option for advanced stage III patients.
What could go wrong: This is a Phase 3 trial, but results are not guaranteed. The treatment involves injections directly into tumors, which may cause local side effects, and the benefit over standard care is still unproven.

This is an AI summary of the original study and may miss details. Read our disclaimer.

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Conditions

The condition(s) this trial relates to.

cutaneous melanoma melanoma

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

MELANOMA STAGE IIIB MELANOMA STAGE IIIC MELANOMA STAGE IIID

Contacts and locations

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Study contacts

Contact

Email: •••••@•••••

Locations

Ambulatory Care Center at NYC Langarone Health
ACTIVE_NOT_RECRUITING

New York, New York, 10016, United States
Duke University Medical Center - Duke Cancer Center
RECRUITING

Durham, North Carolina, 27710, United States
El Hospital Universitario De Gran Canaria Dr. Negrin
RECRUITING

Las Palmas de Gran Canaria, Canarie, 35010, Spain
Fir Huvh Fundacio Institut De Recerca Hospital Universitari Vall De Hebron
RECRUITING

Barcelona, Barcelona, 08035, Spain
Fox Chase Cancer Center 333 Cottman Avenue
RECRUITING

Philadelphia, Pennsylvania, 19111, United States
Fundacion Onkologikoa Fundazioa
RECRUITING

Donostia / San Sebastian, Gipuzkoa, 20014, Spain
Hospital Clinic Barcelona
RECRUITING

Barcelona, Barcelona, 08036, Spain
Hospital Clínico Universitario Virgen de la Arrixaca
RECRUITING

Murcia, Murcia, 30120, Spain
Hospital General Universitario de Valencia
RECRUITING

Valencia, Spain
Hospital Universitari Germans Trias i Pujol
RECRUITING

Badalona, Barcelona, 08916, Spain
Hospital Universitario 12 de Octubre
RECRUITING

Madrid, Madrid, 28041, Spain
Hospital Universitario Regional de Málaga
RECRUITING

Málaga, Malaga, 29010, Spain
Hospital Universitario Virgen De La Macarena
ACTIVE_NOT_RECRUITING

Seville, Sevilla, 41009, Spain
Hospital de la Santa Creu i Sant Pau
RECRUITING

Barcelona, Barcelona, 08025, Spain
Huntsman Cancer Institute, University of Utah 2000 Circle of Hope
RECRUITING

Salt Lake City, UT, Utah, 84112, United States
Hôpitaux Universitaires de Genève
ACTIVE_NOT_RECRUITING

Geneva, Canton of Geneva, 1205, Switzerland
Insel Gruppe AG
ACTIVE_NOT_RECRUITING

Bern, Canton of Bern, 3010, Switzerland
Istituto Oncologico della Svizzera Italiana
RECRUITING

Bellinzona, Bellinzona, 6500, Switzerland
Kantonsspital St.Gallen
RECRUITING

Sankt Gallen, Canton of St. Gallen, 9007, Switzerland
MD Anderson Cancer Center
ACTIVE_NOT_RECRUITING

Madrid, Madrid, 28033, Spain
Mayo Clinic
RECRUITING

Rochester, Minnesota, 55905, United States
Mayo Clinic Hospital
RECRUITING

Phoenix, Arizona, 85054, United States
Memorial Sloan Kettering Cancer Center - Main Campus
RECRUITING

Ney York, New York, 10065, United States
Moffitt Cancer Center
RECRUITING

Tampa, Florida, 33612, United States
Ohio State University Wexner Medical Center
RECRUITING

Columbus, Ohio, 43210, United States
Penn State Cancer Institute
RECRUITING

Hershey, Pennsylvania, 17033, United States
Rush University Medical Center
ACTIVE_NOT_RECRUITING

Chicago, Illinois, 60612, United States
Rutgers Cancer Institute, 195 Little Albany Street
RECRUITING

New Brunswick, New Jersey, 08903, United States
St. Luke's Cancer Center, Clinical Trial, 3rd floor, 1600 St. Luke's Blvd.
ACTIVE_NOT_RECRUITING

Easton, Pennsylvania, 18045, United States
The University of Texas M.D. Anderson Cancer Center
RECRUITING

Houston, Texas, 77030-4009, United States
UC Irvine Health-Chao Family Comprehensive Cancer Center
ACTIVE_NOT_RECRUITING

Orange, California, 92868-3201, United States
UC San Diego Moores Cancer Center
ACTIVE_NOT_RECRUITING

La Jolla, California, 92093, United States
University of Iowa Hospitals and Clinics
ACTIVE_NOT_RECRUITING

Iowa City, Iowa, 52242, United States
Universitätsspital Basel
ACTIVE_NOT_RECRUITING

Basel, Basel, 4031, Switzerland
Universitätsspital Zürich (USZ)
RECRUITING

Zurich, Canton of Zurich, 8091, Switzerland
VCU - McGlothlin Medical Education Center
RECRUITING

Richmond, Virginia, 980037, United States
Winship Cancer Institute, Emory university
RECRUITING

Atlanta, Georgia, 30322, United States

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