Experimental shot before surgery may keep melanoma from coming back
NCT ID NCT03567889
First seen Jun 25, 2026 · Last updated Jun 27, 2026 · Updated 1 time
Summary
This Phase 3 trial tests whether injecting Daromun directly into melanoma tumors before surgery can help prevent the cancer from returning. About 186 people with stage IIIB/C/D melanoma will either get Daromun injections plus standard surgery and follow-up therapy, or just surgery and follow-up therapy. The main goal is to see if the Daromun group has a longer time without the cancer coming back.
What this could mean
Our plain-language read of the trial. This is informational only — not medical advice or a prediction.
Active substance
Daromun (a combination of two immune-targeting proteins, L19IL2 and L19TNF)
What this could lead to
If successful, this approach could reduce the chance of melanoma returning after surgery, offering a new treatment option for advanced stage III patients.
What could go wrong
This is a Phase 3 trial, but results are not guaranteed. The treatment involves injections directly into tumors, which may cause local side effects, and the benefit over standard care is still unproven.
Disclaimer
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the original study
.
Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
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Study contacts
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Contact
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Locations
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Ambulatory Care Center at NYC Langarone Health
ACTIVE_NOT_RECRUITINGNew York, New York, 10016, United States
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Duke University Medical Center - Duke Cancer Center
RECRUITINGDurham, North Carolina, 27710, United States
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El Hospital Universitario De Gran Canaria Dr. Negrin
RECRUITINGLas Palmas de Gran Canaria, Canarie, 35010, Spain
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Fir Huvh Fundacio Institut De Recerca Hospital Universitari Vall De Hebron
RECRUITINGBarcelona, Barcelona, 08035, Spain
Contact Phone: •••-•••-•••• Email: •••••@•••••
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Fox Chase Cancer Center 333 Cottman Avenue
RECRUITINGPhiladelphia, Pennsylvania, 19111, United States
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Fundacion Onkologikoa Fundazioa
RECRUITINGDonostia / San Sebastian, Gipuzkoa, 20014, Spain
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Hospital Clinic Barcelona
RECRUITINGBarcelona, Barcelona, 08036, Spain
Contact Phone: •••-•••-•••• Email: •••••@•••••
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Hospital Clínico Universitario Virgen de la Arrixaca
RECRUITINGMurcia, Murcia, 30120, Spain
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Hospital General Universitario de Valencia
RECRUITINGValencia, Spain
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Hospital Universitari Germans Trias i Pujol
RECRUITINGBadalona, Barcelona, 08916, Spain
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Hospital Universitario 12 de Octubre
RECRUITINGMadrid, Madrid, 28041, Spain
Contact Phone: •••-•••-•••• Email: •••••@•••••
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Hospital Universitario Regional de Málaga
RECRUITINGMálaga, Malaga, 29010, Spain
Contact Phone: •••-•••-•••• Email: •••••@•••••
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Hospital Universitario Virgen De La Macarena
ACTIVE_NOT_RECRUITINGSeville, Sevilla, 41009, Spain
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Hospital de la Santa Creu i Sant Pau
RECRUITINGBarcelona, Barcelona, 08025, Spain
Contact Phone: •••-•••-•••• Email: •••••@•••••
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Huntsman Cancer Institute, University of Utah 2000 Circle of Hope
RECRUITINGSalt Lake City, UT, Utah, 84112, United States
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Hôpitaux Universitaires de Genève
ACTIVE_NOT_RECRUITINGGeneva, Canton of Geneva, 1205, Switzerland
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Insel Gruppe AG
ACTIVE_NOT_RECRUITINGBern, Canton of Bern, 3010, Switzerland
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Istituto Oncologico della Svizzera Italiana
RECRUITINGBellinzona, Bellinzona, 6500, Switzerland
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Kantonsspital St.Gallen
RECRUITINGSankt Gallen, Canton of St. Gallen, 9007, Switzerland
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MD Anderson Cancer Center
ACTIVE_NOT_RECRUITINGMadrid, Madrid, 28033, Spain
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Mayo Clinic
RECRUITINGRochester, Minnesota, 55905, United States
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Mayo Clinic Hospital
RECRUITINGPhoenix, Arizona, 85054, United States
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Memorial Sloan Kettering Cancer Center - Main Campus
RECRUITINGNey York, New York, 10065, United States
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Moffitt Cancer Center
RECRUITINGTampa, Florida, 33612, United States
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Ohio State University Wexner Medical Center
RECRUITINGColumbus, Ohio, 43210, United States
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Penn State Cancer Institute
RECRUITINGHershey, Pennsylvania, 17033, United States
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Rush University Medical Center
ACTIVE_NOT_RECRUITINGChicago, Illinois, 60612, United States
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Rutgers Cancer Institute, 195 Little Albany Street
RECRUITINGNew Brunswick, New Jersey, 08903, United States
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St. Luke's Cancer Center, Clinical Trial, 3rd floor, 1600 St. Luke's Blvd.
ACTIVE_NOT_RECRUITINGEaston, Pennsylvania, 18045, United States
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The University of Texas M.D. Anderson Cancer Center
RECRUITINGHouston, Texas, 77030-4009, United States
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UC Irvine Health-Chao Family Comprehensive Cancer Center
ACTIVE_NOT_RECRUITINGOrange, California, 92868-3201, United States
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UC San Diego Moores Cancer Center
ACTIVE_NOT_RECRUITINGLa Jolla, California, 92093, United States
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University of Iowa Hospitals and Clinics
ACTIVE_NOT_RECRUITINGIowa City, Iowa, 52242, United States
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Universitätsspital Basel
ACTIVE_NOT_RECRUITINGBasel, Basel, 4031, Switzerland
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Universitätsspital Zürich (USZ)
RECRUITINGZurich, Canton of Zurich, 8091, Switzerland
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VCU - McGlothlin Medical Education Center
RECRUITINGRichmond, Virginia, 980037, United States
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Winship Cancer Institute, Emory university
RECRUITINGAtlanta, Georgia, 30322, United States
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