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New injection shows promise for Tough-to-Treat skin cancer

NCT ID NCT07227870

Recruiting now Disease control Sponsor: Philogen S.p.A. Source: ClinicalTrials.gov ↗

First seen Jun 24, 2026 · Last updated Jul 22, 2026 · Updated 3 times

Summary

This phase 2 trial tests a new drug combination, L19IL2/L19TNF, injected directly into skin tumors. It is for people with advanced basal cell carcinoma that has worsened despite or cannot tolerate standard treatments. The study will enroll 92 participants and track how many respond to the therapy over up to 160 weeks.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance
L19IL2/L19TNF (a combination of two immune-boosting proteins injected directly into tumors)
What this could lead to
If it works, this could offer a new treatment option for people with advanced basal cell skin cancer who have run out of other options.
What could go wrong
This is an early phase 2 trial with only 92 participants, so results may not apply to everyone. The treatment is injected directly into tumors, which may not be possible for all patients, and side effects are still being studied.

This is an AI summary of the original study and may miss details. Read our disclaimer.

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Conditions

The condition(s) this trial relates to.

basal cell carcinoma skin basal cell carcinoma

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

LOCALLY ADVANCED BASAL CELL CARCINOMA

Contacts and locations

Study contacts

  • Contact

    Email: •••••@•••••

Locations

  • Andreas Syngros Hospital Of Venereal And Dermatological Diseases

    NOT_YET_RECRUITING

    Athens, 16121, Greece

  • Azienda Ospedaliero-Universitaria Senese

    RECRUITING

    Siena, 53100, Italy

  • Charite Universitaetsmedizin Berlin KöR

    RECRUITING

    Berlin, 10117, Germany

  • Fondazione Policlinico Universitario Agostino Gemelli IRCCS

    RECRUITING

    Roma, 00168, Italy

  • H. Lee Moffitt Cancer Center and Research Institute Hospital, Inc.

    RECRUITING

    Tampa, Florida, 33612, United States

  • Heidelberg University

    RECRUITING

    Heidelberg, 69120, Germany

  • Hospital Clinic De Barcelona

    RECRUITING

    Barcelona, 08036, Spain

  • Humanitas Mirasole S.p.A.

    RECRUITING

    Rozzano, 20089, Italy

  • IRCCS Istituto Nazionale Tumori Fondazione Pascale

    RECRUITING

    Naples, 80131, Italy

  • Memorial Sloan Kettering

    NOT_YET_RECRUITING

    New York, New York, 10065, United States

  • The Ohio State University Wexner Medical Center Clinical Laboratories

    NOT_YET_RECRUITING

    Columbus, Ohio, 43221, United States

  • The University of Texas MD Anderson Cancer Center

    RECRUITING

    Houston, Texas, 77030, United States

  • Universitaetsklinikum Augsburg

    RECRUITING

    Augsburg, 86179, Germany

  • Universitaetsklinikum Essen AöR

    RECRUITING

    Essen, 45147, Germany

  • Universitaetsklinikum Halle (Saale) AöR

    RECRUITING

    Halle, 06120, Germany

  • Universitaetsklinikum Schleswig-Holstein AöR

    RECRUITING

    Kiel, 24105, Germany

  • Universitaetsklinikum Tuebingen AöR

    RECRUITING

    Tübingen, 72076, Germany

  • Winship Cancer Institute, Emory University

    RECRUITING

    Atlanta, Georgia, 30322, United States

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