New injections aim to shrink Hard-to-Treat skin tumors
NCT ID NCT07227350
First seen Jun 27, 2026 · Last updated Jun 27, 2026
Summary
This phase 2 trial tests three experimental drugs—L19IL2, L19TNF, or a combination—injected directly into skin tumors for people with advanced basal cell carcinoma who cannot have surgery or radiation. About 180 participants will receive weekly injections for four weeks and be followed for up to three years. The goal is to see if these drugs can shrink or control the tumors.
What this could mean
Our plain-language read of the trial. This is informational only — not medical advice or a prediction.
Active substance
L19IL2 and L19TNF (immune-targeting drugs injected directly into tumors)
What this could lead to
If successful, this could offer a new treatment option for people with advanced basal cell skin cancer who cannot have surgery or radiation.
What could go wrong
This is an early phase 2 trial with only 180 participants, so results may not apply to everyone. The drugs are injected directly into tumors, which may cause local side effects like pain or swelling, and the treatment may not shrink tumors in all patients.
Disclaimer
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This is a summary of
the original study
.
Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
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Study contacts
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Contact
Phone: •••-•••-•••• Email: •••••@•••••
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Contact
Phone: •••-•••-•••• Email: •••••@•••••
Locations
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H. Lee Moffitt Cancer Center and Research Institute Hospital, Inc.
NOT_YET_RECRUITINGTampa, Florida, 33612, United States
Contact
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The University of Texas MD Anderson Cancer Center
RECRUITINGHouston, Texas, 77030, United States
Contact
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Winship Cancer Institute, Emory University
NOT_YET_RECRUITINGAtlanta, Georgia, 30322, United States
Contact