Mayo Clinic

This study looks at whether taking melatonin for 12 weeks can improve blood pressure in women aged 40-55 who are going through menopause and have high blood pressure. Researchers will measure nighttime blood pressure and markers of oxidative stress. The goal is to find a simple, …

This early-stage trial tests a new drug called Q702 in people with certain blood cancers or histiocytic disorders that have not responded to standard treatments. The drug works by helping the immune system attack cancer cells and supporting normal blood cell production. The study…

This study looks at whether older kidney transplant patients (55+) can safely stop taking one of their anti-rejection drugs (mycophenolate mofetil) while still protecting their new kidney. About 350 participants will either stop the drug or continue standard care, and researchers…

This study tests a treatment called HIPEC, which delivers heated chemotherapy directly into the abdomen during surgery. It is for people with pancreatic cancer that has spread to the lining of the belly. The goal is to see if this approach helps patients live longer and controls …

This study tests whether a home-based pulmonary rehabilitation program combined with health coaching can improve breathing-related quality of life and daily physical activity in people with fibrotic interstitial lung disease. About 460 participants will be randomly assigned to ei…

This study tests whether wearing noise-cancelling headphones with music or a movie during knee replacement surgery can help patients stay comfortable with less sedation. About 200 adults having their first knee replacement under spinal anesthesia will participate. The goal is to …

This early study tests whether a wearable EEG headband (MUSE-S) can help breast cancer survivors manage anxiety and insomnia. About 20 survivors who have had breast cancer in the past 10 years and currently struggle with anxiety and poor sleep will use the headband for guided med…

This study tests whether metformin, a diabetes drug, along with wearable activity trackers, can reduce memory and thinking problems caused by brain radiation. About 100 adults who have had or will have cranial radiation for a brain tumor will participate remotely using online tes…

This study looks at how aromatase inhibitor therapy affects skin quality and self-esteem in breast cancer survivors. Researchers will use special imaging to track skin changes in 35 women with early-stage, hormone-positive breast cancer. The goal is to understand and potentially …

This study tests a new, non-invasive way to measure blood flow in the legs of people who may have deep vein thrombosis (a blood clot). Researchers will use an air-filled bladder under a compression cuff to see how well blood moves. The goal is to improve detection of clots withou…

This study compares noninvasive heart ultrasound (echocardiogram) with the standard invasive right heart catheterization in 3000 people referred for catheterization. The goal is to see if ultrasound can accurately measure heart function and blood flow during exercise. Participant…

This study looks at how oxidative stress and the body's antioxidant defenses work in the early stages of autosomal dominant polycystic kidney disease (ADPKD). Researchers will collect blood and urine samples from 40 adults aged 18-30 with ADPKD and measure kidney size by MRI. The…

This study looks at the gut microbiome (the bacteria living in the digestive system) of people with POEMS syndrome, multiple myeloma, MGUS, AL amyloidosis, and healthy household members. Participants provide stool samples at home using a collection kit. The goal is to understand …

This study looks at how the body controls blood pressure after a spinal cord injury and whether those changes can predict future health problems. Researchers will monitor 18 adults with recent or long-term spinal cord injuries using simple, non-invasive tests. The goal is to bett…

This study tests a new, non-invasive heart scan called magnetocardiography (MCG) to see if it can detect and track amyloidosis, a rare disease where abnormal proteins build up in organs. Researchers at Mayo Clinic will compare MCG with standard ECG in 500 adults. This is an obser…

This study looks at how your stomach and brain work together to control hunger and fullness. Researchers will use MRI scans to see which brain areas light up when the stomach is stretched, when you taste something with no calories, or when you eat tasty food. The goal is to bette…