Liverpool School Of Tropical Medicine

This phase 2 trial tests two oral drugs, DMPS and marimastat, to see if they can reduce the harmful effects of snake venom. 504 adults in Brazil and Ghana who have been bitten by a snake will receive either the drug, a placebo, or standard antivenom. The goal is to find a treatme…

This large study in five countries will test new, portable diagnostic tools for tuberculosis (TB) that use tongue swabs and AI-assisted chest X-rays. The goal is to see if these faster, easier tests can find more TB cases, especially in people who have no symptoms or can't produc…

This study will test a new, portable device that can detect tuberculosis (TB) in about 15-35 minutes using a simple tongue or sputum swab. It aims to enroll 60,000 people in Bangladesh, Cameroon, and Nigeria who are screened in community settings. The goal is to see if this rapid…

This study aims to find better ways to diagnose tuberculosis (TB) in children and young teens. It will test new tools like computer-aided chest X-ray reading and non-sputum samples (e.g., stool or urine) in Bangladesh, Cameroon, Kenya, and Vietnam. About 7,920 participants aged 1…

This study will test whether a new urine-based test can accurately diagnose pneumococcal pneumonia in children under 5 in Malawi. Researchers will use 350 stored urine samples from healthy kids and those with pneumonia, comparing results to standard lab methods. If it works, this…

This study tests new devices called LASER that release a chemical to repel mosquitoes, comparing them to indoor insecticide spraying and standard prevention (bed nets, vaccines). About 22,800 people in 69 Kenyan villages will take part over two years. Researchers will check malar…

This study looks at whether CPAP, a machine that pushes air through a mask at night, can help people with large airway collapse (LAC). LAC causes shortness of breath, cough, and wheeze, and is often mistaken for asthma. The study will test if a larger trial is possible by checkin…

This study aims to see if a mobile health (mHealth) tool, combined with decision aids, can help college students in Zimbabwe better access HIV prevention and contraception services. Researchers will work with 16,000 students to develop and test the tool over several stages, inclu…

This study will test a new way to care for people in Ghana who have both a neglected tropical skin disease (like leprosy or Buruli ulcer) and mental health challenges like depression or anxiety. Researchers will work with 200 affected adults and local health workers to create a G…

This study looks at why some people with a rare virus called hantavirus develop serious bleeding and kidney failure. Researchers will study blood samples from 62 hospitalized patients in Slovenia to understand how clotting goes wrong. The goal is to better predict who is at risk …

This study will survey 32,000 households in Ghana and Rwanda to understand where snakebites happen most. Researchers will use GPS and computer models to create risk maps. The goal is to help health officials send antivenom to the areas that need it most and plan prevention effort…