Janssen Research & Development, Llc

This study tested a drug called erdafitinib in people with a specific type of bladder cancer that came back after standard BCG therapy. The drug targets certain genetic changes (FGFR mutations) found in the tumor. Researchers compared erdafitinib to standard chemotherapy given di…

This early-phase study tested a new treatment called JNJ-75229414 for men with a type of advanced prostate cancer that no longer responds to hormone therapy. The treatment uses the patient's own immune cells, modified to target a protein on cancer cells. The main goals were to fi…

This early-stage study tested an experimental drug called JNJ-75348780 in 147 people with relapsed or refractory B-cell non-Hodgkin lymphoma or chronic lymphocytic leukemia. The drug is a bispecific antibody designed to help the immune system attack cancer cells. The main goal wa…

This study tested an experimental drug called M281 (nipocalimab) in 25 pregnant women whose babies were at high risk for a severe blood disorder that can cause anemia and death. The goal was to see if the drug could help more babies survive to at least 32 weeks without needing a …

This study tested a drug called golimumab, given through a vein (IV), in 208 adults with active ankylosing spondylitis, a type of arthritis that causes back pain and stiffness. The goal was to see if it could reduce pain and improve movement better than a placebo. Golimumab works…

This study tested a drug called golimumab in 130 children with active juvenile idiopathic arthritis (JIA) that was not controlled by methotrexate alone. The drug was given through a vein (IV) to see how it moves through the body and if it helps control joint inflammation. The goa…

This study tested a new combination of drugs (daratumumab, lenalidomide, and dexamethasone) in 45 adults whose multiple myeloma had returned or stopped responding to treatment. The main goal was to check safety and find the right dose, while also measuring how well the drugs shra…

This study tested a medicine called ustekinumab in 112 children with moderate to severe ulcerative colitis, a condition that causes inflammation and sores in the colon. The goal was to see if the drug could help children reach remission (no symptoms) and to check its safety. Chil…

This study tested whether adding daratumumab to standard chemotherapy (CyBorD) helps people newly diagnosed with AL amyloidosis, a rare disease where abnormal proteins build up in organs. Over 400 adults took part. The goal was to see if the combination leads to better blood resp…

This study tested a new drug, nipocalimab, against a placebo in 228 adults with active systemic lupus erythematosus (SLE). The goal was to see if nipocalimab could reduce lupus disease activity without worsening symptoms. Participants received either the drug or a placebo, and re…

This study tested an experimental drug, JNJ-77242113, in 255 adults with moderate-to-severe plaque psoriasis. The goal was to see if different doses could improve skin symptoms, like redness and scaling, after 16 weeks of treatment. Participants were randomly assigned to receive …

This study tested whether combining two drugs, guselkumab and golimumab, works better than guselkumab alone for people with active psoriatic arthritis who didn't improve with previous treatments. 91 adults participated in this phase 2a trial. The goal was to see if the combinatio…

This study tested the drug guselkumab in 213 adults with skin of color who have moderate-to-severe plaque or scalp psoriasis. Participants received either the drug or a placebo, and researchers measured how much their psoriasis cleared up after 16 weeks. The goal was to see if gu…

This study tested a new vaccine called ExPEC10V in 836 adults aged 60 to 85. The goal was to see if it is safe and helps the body fight off a type of E. coli that can cause serious infections, especially in the urinary tract. Researchers gave different doses to find the best one …

This study tested whether adding seltorexant, a sleep aid, to standard antidepressants helps adults with major depression who still have insomnia and depressive symptoms. About 588 participants took either seltorexant or a placebo for 6 weeks, then some continued on seltorexant l…

This study tested whether adding aticaprant to a standard antidepressant helps adults with major depression who still feel little interest or pleasure (anhedonia). About 444 people took either aticaprant or a placebo pill for 6 weeks. Researchers measured changes in depression an…

This study tested a drug called guselkumab against a placebo in 338 adults with moderate plaque psoriasis that also affects special areas like the scalp or genitals. The goal was to see if the drug could clear or nearly clear the skin. Results showed that guselkumab was more effe…

This early-stage study tested how long-acting versions of two HIV drugs, rilpivirine and cabotegravir, behave when given as shots under the skin. 126 healthy adults received one or both drugs to measure drug levels and check for side effects. The goal was to gather safety and dos…