Jaeb Center For Health Research

This study looks at whether inhaled insulin (Afrezza) is safer than standard pump insulin for preventing low blood sugar during exercise after a meal. About 30 adults with type 1 diabetes who use a Tandem pump with Control-IQ will complete three exercise sessions in a clinic. The…

This study tests two ways to treat proliferative diabetic retinopathy, a serious eye problem caused by diabetes. One group gets eye injections of faricimab plus laser treatment; the other gets eye surgery plus laser. Researchers will track vision and how many extra treatments are…

This study tests if watching specially designed videos (dichoptic treatment) can improve vision in children aged 8 to 12 with lazy eye (amblyopia). About 252 kids will be randomly assigned to use one of two video treatments or just wear glasses (if needed). The main goal is to se…

This study looks at the best way to treat lazy eye (amblyopia) in children aged 3 to 12 who haven't been treated before. It compares giving glasses and an eye patch at the same time versus starting with glasses alone and adding a patch later if needed. The goal is to see if both …

This study tests a new way to treat lazy eye (amblyopia) in children aged 4 to 7. Instead of wearing an eye patch for 2 hours daily, kids watch specially designed movies or shows through a headset for 1 hour a day, 6 days a week. The goal is to see if this dichoptic treatment imp…

This study tests two treatments—special glasses with unique lenslets and low-dose atropine eyedrops—to see if they can slow the progression of nearsightedness (myopia) in children. About 348 kids aged 5 to 12 will use one or both treatments for 2 years. The goal is to reduce how …

This study tests whether daily home eye scans can guide when to give injections for wet age-related macular degeneration, compared to the standard treat-and-extend schedule. Six hundred adults aged 50 and older with wet AMD will use a home OCT device daily for two years. The goal…

This study tests whether wearing a continuous glucose monitor (CGM) early in pregnancy can quickly detect and manage high blood sugar in 6,000 pregnant women. The goal is to reduce serious problems for the baby (like being too large, birth injuries, or NICU stays) and for the mot…

This study tests a smart insulin pump called the iLet Bionic Pancreas in 150 people aged 14 and older with cystic fibrosis-related diabetes. The pump automatically adjusts insulin based on continuous glucose monitor readings. Participants are randomly assigned to use the bionic p…

This study tests two treatments—faricimab injections or a fluocinolone acetonide implant—to prevent vision loss in people who had radiation therapy for eye cancer. About 600 participants will be randomly assigned to one of these treatments or to observation only. The goal is to s…

This study tests whether fenofibrate, a drug already used for high cholesterol, can prevent diabetic retinopathy from worsening in people with mild to moderate disease. About 560 adults with diabetes will take either fenofibrate or a placebo for up to 6 years. The goal is to see …

This study looks at children under 18 with uveitis, an eye inflammation. Researchers want to learn about the different types of uveitis and the children who get it. Participants will have one visit with their doctor, and some will have their medical records reviewed for a year. N…

This study will check how often people with cystic fibrosis-related diabetes (CFRD) develop eye, kidney, and nerve problems. Researchers will also look at blood pressure and cholesterol. About 200 teens and adults with CFRD for at least 5 years will take part. The goal is to bett…

This study is for people with rare inherited retinal diseases, like retinitis pigmentosa, caused by specific gene changes. Researchers will collect genetic and vision data from 1,500 participants over time to learn how these conditions progress. No treatment is given—the goal is …

This study compares immediate surgery versus waiting for vision to worsen in people with an epiretinal membrane (a thin layer of scar tissue on the eye's surface). It includes 400 adults with relatively good vision (20/40 or better) who have symptoms like blurring or distortion. …