Cheap pill could save millions from blindness, major trial launches

NCT ID NCT04661358

Ongoing Prevention Sponsor: Jaeb Center for Health Research Source: ClinicalTrials.gov ↗

First seen Jun 27, 2026 · Last updated Jun 30, 2026 · Updated 2 times

Summary

This study tests whether fenofibrate, a drug already used for high cholesterol, can prevent diabetic retinopathy from worsening in people with mild to moderate disease. About 560 adults with diabetes will take either fenofibrate or a placebo for up to 6 years. The goal is to see if the drug can reduce the need for invasive eye treatments like laser surgery or injections.

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Conditions

The condition(s) this trial relates to.

background diabetic retinopathy diabetic retinopathy prevention target

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

DIABETIC RETINOPATHY

Contacts and locations

Locations

Austin Research Center for Retina

Austin, Texas, 78705, United States
Austin Retina Associates

Austin, Texas, 78705, United States
Baylor College of Medicine, Baylor Eye Physicians and Surgeons

Houston, Texas, 77030-4101, United States
Boston Medical Center Corporation

Boston, Massachusetts, 02118, United States
Cascade Medical Research Institute, LLC

Springfield, Oregon, 97477, United States
Dean A. McGee Eye Institute

Oklahoma City, Oklahoma, 73104, United States
Elman Retina Group, P.A.

Baltimore, Maryland, 21237, United States
Eye Clinic of Wisconsin

Wausau, Wisconsin, 54403, United States
Florida Retina Consultants

Lakeland, Florida, 33805, United States
Florida Retina Institute, James A. Staman, MD, PA- Jacksonville

Jacksonville, Florida, 32216, United States
Florida Retina Institute, James A. Staman, MD, PA- Orlando

Orlando, Florida, 32806-1101, United States
Foundation for Vision Research and Retina Specialists of Michigan, P.C.

Grand Rapids, Michigan, 49546, United States
Gunderson Health System

La Crosse, Wisconsin, 54601, United States
Henry Ford Health System

Detroit, Michigan, 48202-2689, United States
Illinois Retina Associates SC - Oak Park Site

Oak Park, Illinois, 60304, United States
John Kenyon American Eye Institute, LLC

New Albany, Indiana, 47150, United States
Joseph E. Humble and Raymond Haik PTRS DBA Eye Assoc of Northeast Louisiana

West Monroe, Louisiana, 71291-4452, United States
Joslin Diabetes Center

Boston, Massachusetts, 02215, United States
Kent W. Small, MD, AMC

Glendale, California, 91203-1971, United States
Loma Linda University

Loma Linda, California, 92354, United States
MaculaCare

New York, New York, 10021, United States
Marietta Eye Clinic

Marietta, Georgia, 30060, United States
Mayo Clinic

Rochester, Minnesota, 55905, United States
Mid-America Retina Consultants, P.A.

Overland Park, Kansas, 66211, United States
Midwest Eye Institute

Indianapolis, Indiana, 46290, United States
National Ophthalmic Research Institute

Fort Myers, Florida, 33912, United States
Northwestern University

Chicago, Illinois, 60611, United States
Oregon Health & Science University

Portland, Oregon, 97239, United States
Pamela Weber, MD/Island Retina

Shirley, New York, 11967, United States
Pittsburg Clinical Trial Consortium

Sewickley, Pennsylvania, 15143, United States
Regents of the University of California, Davis, DBA University of California, Davis

Sacramento, California, 95817, United States
Retina Associates of Western NY, P.C.

Rochester, New York, 14620-4655, United States
Retina Center, PA DBA Retina Center of Minnesota

Minneapolis, Minnesota, 55404, United States
Retina Consultants of Texas

Beaumont, Texas, 77707, United States
Retina Consultants of Texas, PA

Bellaire, Texas, 77401, United States
Retina Consultants, LLC

Salem, Oregon, 97302, United States
Retina Research Institute, LLC

St Louis, Missouri, 63128-1729, United States
Retina Vitreous Consultants, LLP

Sarasota, Florida, 34233-1261, United States
Retina-Vitreous Consultants, Inc.

Monroeville, Pennsylvania, 15146, United States
Retina-Vitreous Surgeons of Central NY, PC

Liverpool, New York, 13088, United States
Retinal Consultants of San Antonio

San Antonio, Texas, 78240, United States
Rush University Medical Center

Chicago, Illinois, 60612, United States
SEASHORE RETINA LLC DBA Retina Specialists of Tampa

Wesley Chapel, Florida, 33544, United States
Salehi Retina Institute Inc.

Huntington Beach, California, 92647-8693, United States
Sarasota Retina Institute

Sarasota, Florida, 34239, United States
Southeast Eye Institute, P.A. dba Eye Associates of Pinellas

Pinellas Park, Florida, 33782, United States
Southeast Retina Center, P.C.

Augusta, Georgia, 30909, United States
Southeastern Retina Associates, P.C.

Knoxville, Tennessee, 37922, United States
Texas Retina Associates

Lubbock, Texas, 79424, United States
The Cleveland Clinic Foundation DBA Cleveland Clinic Lerner College of Medicine

Cleveland, Ohio, 44120, United States
The Curators of the University of Missouri

Columbia, Missouri, 65201-5276, United States
The Regents of the University of California, San Francisco

San Francisco, California, 94110, United States
Thomas Eye Group

Sandy Springs, Georgia, 30328, United States
UCLA Stein Eye Institute

Pasadena, California, 91103, United States
UIC - Dept of Ophthalmology & Visual Sciences

Chicago, Illinois, 60612, United States
University of Florida- Jacksonville

Jacksonville, Florida, 32209, United States
University of Kansas Medical Center Research Institute, Inc.

Prairie Village, Kansas, 66208, United States
University of North Carolina at Chapel Hill

Chapel Hill, North Carolina, 27517, United States
University of Washington

Seattle, Washington, 98104, United States
Valley Eye Physicians and Surgeons

Ayer, Massachusetts, 01432, United States
Vanderbilt Eye Institute

Nashville, Tennessee, 37232, United States
Verum Research LLC

Eugene, Oregon, 97401, United States
Vitreo-Retinal Associates

Grand Rapids, Michigan, 49546, United States
Washington University Ophthalmology

St Louis, Missouri, 63110, United States
Wolfe Clinic, P.C.- West Des Moines

West Des Moines, Iowa, 50266-7705, United States
Wolfe Eye Clinic-Cedar Rapids

Hiawatha, Iowa, 52233, United States

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