Timing of eye surgery under the microscope: early or late?

NCT ID NCT05145491

Recruiting now Knowledge-focused Sponsor: Jaeb Center for Health Research Source: ClinicalTrials.gov ↗

First seen Jun 27, 2026 · Last updated Jul 17, 2026 · Updated 2 times

Summary

This study compares immediate surgery versus waiting for vision to worsen in people with an epiretinal membrane (a thin layer of scar tissue on the eye's surface). It includes 400 adults with relatively good vision (20/40 or better) who have symptoms like blurring or distortion. The goal is to see which timing leads to better vision over 3 years and to learn more about how the condition progresses.

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Conditions

The condition(s) this trial relates to.

preretinal fibrosis

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

EPIRETINAL MEMBRANE

Contacts and locations

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Locations

Austin Research Center for Retina
RECRUITING

Austin, Texas, 78705, United States
Baylor College of Medicine, Baylor Eye Physicians and Surgeons
RECRUITING

Houston, Texas, 77030, United States
Cascade Medical Research Institute, LLC
RECRUITING

Springfield, Oregon, 97477, United States
East Bay Retina Consultants, Inc.
RECRUITING

Oakland, California, 94609-3028, United States
Elman Retina Group, P.A.
RECRUITING

Baltimore, Maryland, 21237, United States
Florida Retina Institute, James A. Staman, MD, PA- Jacksonville
RECRUITING

Jacksonville, Florida, 32216, United States
Hilton Head Retina Institute
RECRUITING

Hilton Head Island, South Carolina, 29926, United States
Illinois Retina Associates SC - Oak Park Site
RECRUITING

Oak Park, Illinois, 60304, United States
Johns Hopkins University
RECRUITING

Baltimore, Maryland, 21287, United States
Joseph E. Humble and Raymond Haik PTRS DBA Eye Assoc of Northeast Louisiana
RECRUITING

West Monroe, Louisiana, 71291-4452, United States
Joslin Diabetes Center
RECRUITING

Boston, Massachusetts, 02215, United States
Kent W. Small, MD, AMC
RECRUITING

Glendale, California, 91203-1971, United States
Loma Linda University
RECRUITING

Loma Linda, California, 92354, United States
Macula Retina Vitreous Institute
RECRUITING

Torrance, California, 90503, United States
Mayo Clinic Arizona
RECRUITING

Scottsdale, Arizona, 85259, United States
Mid-America Retina Consultants, P.A.
RECRUITING

Overland Park, Kansas, 66211, United States
Northwestern University
RECRUITING

Chicago, Illinois, 60611, United States
Ophthalmology Ltd.
RECRUITING

Sioux Falls, South Dakota, 57108, United States
Pittsburg Clinical Trial Consortium
RECRUITING

Sewickley, Pennsylvania, 15143, United States
Raj K. Maturi, M.D., P.C.
RECRUITING

Indianapolis, Indiana, 46290, United States
Regents of the University of California, Davis, DBA University of California, Davis
RECRUITING

Sacramento, California, 95817, United States
Retina Associates of Michigan
RECRUITING

Grand Blanc, Michigan, 48439, United States
Retina Associates of Western NY, P.C.
RECRUITING

Rochester, New York, 14620-4655, United States
Retina Consultants of Texas
RECRUITING

Bellaire, Texas, 77401, United States
Retina Research Institute, LLC
RECRUITING

St Louis, Missouri, 63128-1729, United States
Retina Vitreous Associates, Northern California Retina Vitreous Assoc Medical Group, Inc.
RECRUITING

Mountain View, California, 94040-4123, United States
Retina Vitreous Center
RECRUITING

Edmond, Oklahoma, 73013-9791, United States
Retina-Vitreous Consultants, Inc.
RECRUITING

Monroeville, Pennsylvania, 15146, United States
Retina-Vitreous Surgeons of Central NY, PC
RECRUITING

Liverpool, New York, 13088, United States
Retinal Consultants of San Antonio
RECRUITING

San Antonio, Texas, 78240, United States
Rush University Medical Center
RECRUITING

Chicago, Illinois, 60612, United States
SEASHORE RETINA LLC DBA Retina Specialists of Tampa
RECRUITING

Wesley Chapel, Florida, 33544, United States
Salehi Retina Institute Inc.
RECRUITING

Huntington Beach, California, 92647-8693, United States
Sarasota Retina Institute
RECRUITING

Sarasota, Florida, 34239, United States

Contact Email: •••••@•••••
South Tyneside and Sunderland NHS Trust
RECRUITING

Sunderland, Tyne and Wear, SR29HP, United Kingdom
Southeast Retina Center, P.C.
RECRUITING

Augusta, Georgia, 30909, United States
Spokane Eye Clinical Research, PLLC
RECRUITING

Spokane, Washington, 99204, United States
Texas Retina Associates
RECRUITING

Lubbock, Texas, 79424, United States
The Curators of the University of Missouri
RECRUITING

Columbia, Missouri, 65201-5276, United States
The Retina Group of Washington
RECRUITING

Reston, Virginia, 20190, United States
The Trustees of the University of Pennsylvania
RECRUITING

Philadelphia, Pennsylvania, 19104, United States
Thomas Eye Group
RECRUITING

Sandy Springs, Georgia, 30328, United States
UIC - Department of Ophthalmology and Visual Sciences
RECRUITING

Chicago, Illinois, 60612, United States
University of Kansas Medical Center Research Institute, Inc.
RECRUITING

Prairie Village, Kansas, 66208, United States
University of North Carolina at Chapel Hill
RECRUITING

Chapel Hill, North Carolina, 27517, United States
Valley Eye Physicians and Surgeons
RECRUITING

Ayer, Massachusetts, 01432, United States

Contact Email: •••••@•••••
Vanderbilt Eye Institute
RECRUITING

Nashville, Tennessee, 37232, United States
Verum Research LLC
RECRUITING

Eugene, Oregon, 97401, United States

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