Institute Of Liver And Biliary Sciences, India

This study tests a blood-filtering therapy called DPMAS for people with acute-on-chronic liver failure, a life-threatening condition where the liver suddenly stops working. About 56 adults will be randomly assigned to receive either standard care alone or standard care plus DPMAS…

This study looks at whether oral semaglutide, a drug already used for diabetes, can slow down kidney disease in people who also have fatty liver disease. About 90 adults with both conditions will receive either standard care plus semaglutide or standard care alone for two years. …

This study tests whether adding midodrine to the standard drug carvedilol can prevent early rebleeding in people with liver cirrhosis who have had a variceal bleed. About 210 adults with moderate to severe cirrhosis will be randomly assigned to receive either both drugs or carved…

This study tests whether adding vitamin C to standard treatment can help patients with severe liver disease (ACLF) who have a serious infection (septic shock) and kidney injury. Vitamin C is a safe, cheap antioxidant that may reduce inflammation and protect the kidneys. The study…

This study tests whether the drug finerenone can prevent chronic kidney disease in 160 adults with fatty liver disease (MASLD), cirrhosis, and fluid in the belly (ascites). Participants will receive either finerenone or spironolactone alongside standard care. The main goal is to …

This study tests whether starting midodrine early can better control ascites (fluid buildup in the belly) and prevent kidney complications in people with acute-on-chronic liver failure. About 113 adults with moderate to severe ascites will receive either standard care or standard…

This study compares a higher volume of plasma exchange to the standard volume in 60 adults with sudden liver failure and brain swelling. The goal is to see if the higher dose reduces brain swelling faster and improves survival without needing a liver transplant. Participants will…

This study looks at how many adults with cirrhosis have natural protection against hepatitis A and how well a single dose of the vaccine works for those who are not immune. Researchers will test blood samples from 360 participants in India. The goal is to provide better guidance …

This study will follow 100 adults with chronic liver disease who are hospitalized for sudden worsening of their condition. Researchers will track their health for 6 months to see who recovers, who needs a liver transplant, or who dies. The goal is to better understand how liver f…