Guangdong Provincial People's Hospital

This study tests a two-step treatment for people with a specific type of lung cancer (EGFR-mutant, stage II-IIIB). First, patients take a targeted pill (almonertinib), then receive a combination of immunotherapy (adebrelimab) and chemotherapy. After these treatments, they have su…

This phase 2 trial is testing whether adding two drugs—a PCSK9 inhibitor and a PD-1 inhibitor—to standard chemoradiotherapy can help shrink tumors in patients with locally advanced rectal cancer that has a specific genetic profile (pMMR/MSS). The study involves 30 participants an…

This phase 2 trial is testing whether taking the targeted drug lorlatinib for three months before surgery can shrink tumors in people with stage III ALK-positive non-small cell lung cancer. The study involves 48 participants and aims to see if the drug can eliminate all signs of …

This study looks at whether adding venetoclax to standard chemotherapy (HMAs) works better than chemotherapy alone for people newly diagnosed with higher-risk myelodysplastic syndromes (MDS) or chronic myelomonocytic leukemia (CMML). About 224 adults are being observed to see how…

This phase 2 trial tests whether adding the immunotherapy drug serplulimab to standard FLOT chemotherapy can improve outcomes for people with stage III gastric cancer. About 138 participants will receive either the combo or chemo alone before surgery. The main goal is to see if t…

This study tests whether adding N-acetylcysteine (NAC) to standard treatment can help people with obsessive-compulsive disorder (OCD) that hasn't improved with other medications. Researchers will measure brain glutamate levels and symptom changes in 90 participants over 12 weeks.…

This large observational study involving 150,000 people tests whether artificial intelligence can predict new heart attacks by analyzing electrocardiogram (ECG) images. The AI model, called AMIdECG, looks at past ECG data that was considered normal to see if it can forecast a fut…

This study tests whether a drug called crisugabalin can safely reduce pain in people with Parkinson's disease who have a type of pain called nociplastic pain. About 166 adults will take either the drug or a placebo twice a day for 12 weeks. Researchers will measure pain levels an…

This study will observe 200,000 Chinese adults with heart disease to see how their heart and lung function changes over 5 years. Participants will take a special exercise test to measure their fitness. Researchers hope to find better ways to predict future heart problems like hea…

This study follows 330 people with non-small cell lung cancer who receive immunotherapy before surgery. Researchers measure cortisol levels at different times to see if changes in this stress hormone relate to how well the tumor shrinks or if side effects occur. The goal is to fi…