Immunotherapy plus chemo shows promise against tough stomach cancer
NCT ID NCT07257575
First seen Jun 25, 2026 · Last updated Jun 27, 2026 · Updated 1 time
Summary
This phase 2 trial tests whether adding the immunotherapy drug serplulimab to standard FLOT chemotherapy can improve outcomes for people with stage III gastric cancer. About 138 participants will receive either the combo or chemo alone before surgery. The main goal is to see if the combo leads to a higher rate of complete cancer disappearance in tissue samples after treatment.
What this could mean
Our plain-language read of the trial. This is informational only — not medical advice or a prediction.
Active substance
Serplulimab (an immunotherapy drug) combined with FLOT chemotherapy (fluorouracil, leucovorin, oxaliplatin, docetaxel)
What this could lead to
If successful, this combination could increase the chance of eliminating all visible cancer before surgery, potentially improving long-term outcomes for patients with advanced gastric cancer.
What could go wrong
This is a mid-stage trial with only 138 participants, so results may not apply broadly. Immunotherapy can cause immune-related side effects, and the added benefit over chemotherapy alone is not yet proven.
Disclaimer
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the original study
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Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
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Locations
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No. 106, Zhongshan 2nd Road, Yuexiu District
Guangzhou, Guangdong, 510080, China