Gruppo Italiano Malattie Ematologiche Dell'adulto

This study tests a new combination treatment for adults aged 18-65 with a specific, high-risk type of acute lymphoblastic leukemia (ALL) called BCR/ABL1-like. The treatment adds the targeted drug ponatinib to standard chemotherapy. The goal is to see if this approach can make the…

This study tests whether adding daratumumab to standard chemotherapy can eliminate all signs of leukemia in adults with a very high-risk form of T-cell acute lymphoblastic leukemia. About 31 participants aged 18 to 65 will receive the drug combination during their first treatment…

This study tests a personalized treatment plan for young adults (18-65) with high-risk chronic lymphocytic leukemia (CLL) who have not had prior therapy. Patients first receive a combination of two drugs (venetoclax and obinutuzumab). Then, based on whether any cancer cells remai…

This study looks at how a protein called adrenomedullin affects leukemia cells in the bone marrow of 72 adults with acute myeloid leukemia. Researchers will collect blood and bone marrow samples to measure protein levels and study cell behavior in the lab. The goal is to learn mo…

This study is an observational registry for 572 Italian patients with Philadelphia-negative myeloproliferative neoplasms (MPN). Its main goal is to collect information on how the disease and its treatments impact patients' quality of life, symptoms, and daily functioning. No expe…