Children's Hospital Of Orange County

This study tests the drug fenfluramine in 10 children aged 12 to 36 months whose infantile spasms did not get better with standard treatments. The children take fenfluramine for 21 days, and doctors check brain waves and seizure diaries to see if the spasms stop. If it helps, the…

This study tests whether acupuncture can reduce stomach pain in children aged 8-17 with disorders of gut-brain interaction, like irritable bowel syndrome. Half of the 96 participants will get real acupuncture, and half will get a sham (fake) treatment. Researchers will measure pa…

This study tests a small device that sends gentle electrical pulses to nerves in the ear to help children ages 11-18 with post-concussion syndrome or long COVID symptoms like pain, nausea, and balance problems. Participants must have had symptoms for at least 3 months. The goal i…

This phase 2 trial tests whether suramin (KZ101) can improve social skills in 45 boys aged 5–14 with autism. Participants receive either suramin or a placebo by IV, then switch after a period. The main goal is to see changes in social behavior using a standard test. The study bui…

This study looks at how heart and blood vessel problems develop in people with MPS I and IVA. Over 4 years, 240 participants will get yearly heart ultrasounds, blood tests, and urine tests. The goal is to find reliable markers that can track heart health and guide future treatmen…