Old drug, new hope? suramin trial targets autism social symptoms
NCT ID NCT06866275
First seen Jun 27, 2026 · Last updated Jun 27, 2026
Summary
This phase 2 trial tests whether suramin (KZ101) can improve social skills in 45 boys aged 5–14 with autism. Participants receive either suramin or a placebo by IV, then switch after a period. The main goal is to see changes in social behavior using a standard test. The study builds on earlier promising results in mice and a small human trial.
What this could mean
Our plain-language read of the trial. This is informational only — not medical advice or a prediction.
Active substance
Suramin (KZ101)
What this could lead to
If it works, this could point toward a new treatment to ease social and communication challenges in children with autism.
What could go wrong
This is an early phase 2 trial with only 45 boys, so results may not apply to everyone. Suramin can cause side effects, and previous studies were small.
Disclaimer
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This is a summary of
the original study
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Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
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Study contacts
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Contact
Phone: •••-•••-•••• Email: •••••@•••••
Locations
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Children's Hospital Orange County, Thompson Autism and Neurodevelopmental Center
RECRUITINGOrange, California, 92868, United States
Contact Phone: •••-•••-•••• Email: •••••@•••••
Contact
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Kennedy Krieger Institute
RECRUITINGBaltimore, Maryland, 21205, United States
Contact Phone: •••-•••-•••• Email: •••••@•••••
Contact Phone: •••-•••-•••• Email: •••••@•••••
Contact
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Southwest Autism Research and Resource Center
NOT_YET_RECRUITINGPhoenix, Arizona, 85006, United States
Contact
Contact Phone: •••-•••-•••• Email: •••••@•••••