Children's Hospital Of Orange County

This study tests the drug fenfluramine in children aged 12 to 36 months whose infantile spasms have not improved with standard treatments. Over 21 days, researchers will check if the drug stops the spasms and improves brain wave patterns. Children who respond well may continue tr…

This study tests whether real acupuncture can reduce stomach pain and improve daily life for children aged 8-17 with disorders of gut-brain interaction, like irritable bowel syndrome. Half the 96 participants will get real acupuncture, the other half a sham (fake) treatment, alon…

This study tests whether a drug called suramin (KZ101) can improve social skills in boys aged 5-14 with autism. The trial involves 45 participants who will receive the drug or a placebo, then switch after a period. The goal is to see if suramin can help with social interaction an…

This study tests a small device worn on the ear that sends gentle electrical pulses to nerves. The goal is to see if it can reduce pain and other symptoms in children ages 11-18 who have had a concussion or long COVID for at least 3 months. The study will measure changes in balan…

This study looks at how heart and blood vessel problems develop in people with MPS types I and IVA. Researchers will use yearly ultrasounds, blood draws, and urine tests for 4 years to track changes and find markers that could guide future treatments. The study involves 240 parti…