Basilea Pharmaceutica

This study tested a new antifungal drug called APX001 in 21 adults with a serious bloodstream fungal infection (candidemia), including cases where standard treatments might not work. Participants received the drug for up to 14 days, with possible extra treatment afterward. The go…

This study tested a new drug called APX001 in 9 adults with a serious fungal infection (Candida auris) in the blood or organs that didn't respond to standard treatments. The goal was to see if the drug could clear the infection and help patients survive. The study was small and e…

This early-stage study tested a new drug, VNRX-7145, in 83 healthy adults to see if it is safe and how the body handles it. Participants received either a single dose or multiple doses over 10 days. The main goal was to check for side effects and measure drug levels in the blood.

This early-stage study tested a new oral drug called APX001 in 46 healthy volunteers to see if it is safe and how the body handles it. Some participants received the drug and others received a placebo (a dummy pill). The study also looked at how food affects the drug and whether …

This study looked at how a single dose of the antibiotic combination ceftibuten/VNRX-7145 moves through the body in 32 adults with normal kidney function, mild to severe kidney problems, or end-stage kidney disease on dialysis. Researchers measured drug levels in the blood and ch…

This study tested a new antifungal drug called fosmanogepix in 54 healthy Chinese adults to see how the body processes it and if it is safe. Participants received either a single dose or multiple doses of the drug or a placebo. The study did not aim to treat any disease, only to …

This study looked at how a single dose of the antifungal drug fosmanogepix is handled by the body in 28 adults with varying degrees of liver impairment. Participants took one pill, and researchers measured drug levels in the blood over time. The goal was to understand if liver fu…

This study looked at how taking a new antibiotic combination (ceftibuten/VNRX-7145) with or without food changes the way the body absorbs the medicine. It involved 24 healthy adults who received a single dose under both conditions. The goal was to gather safety and drug-level inf…

This study looked at how two antibiotics, ceftibuten and ledaborbactam, travel through the blood and lungs in 34 healthy adults aged 18 to 55. Participants took the drugs by mouth and then had a bronchoscopy to collect lung fluid samples. The goal was to measure drug levels in th…

This early-stage study looked at how safe two experimental antibiotics, VNRX-7145 and ceftibuten, are when given alone or together. Fifty-three healthy adults aged 18 to 55 took part. The goal was to measure how the drugs move through the body and check for side effects, not to t…

This early-stage study tested the safety of an experimental drug called VNRX-5024 in 36 healthy adults aged 18 to 55. Participants received either a single dose or multiple doses over 10 days, and researchers monitored for side effects and how the drug moved through the body. The…

This early-stage study tested the safety and tolerability of a new antifungal drug called APX001 in 200 healthy adults. Participants received either the drug or a placebo by IV infusion, and researchers monitored for side effects and how the drug moved through the body. The goal …

This study looked at how the antibiotic ceftobiprole affects the way the body processes the cholesterol drug pitavastatin. Twelve healthy adults received both drugs, and researchers measured drug levels in the blood to check for interactions. The goal was to understand safety and…