Basilea Pharmaceutica

This study tested a new antifungal drug called APX001 for treating serious yeast infections in the bloodstream (candidemia), including infections that might not respond to standard antifungal medicines. It involved 21 adult patients who were not severely immunocompromised. The ma…

This study tested an experimental drug called APX001 for serious bloodstream and invasive infections caused by Candida auris, a dangerous and often drug-resistant fungus. The trial involved 9 adult patients who had limited treatment options with standard antifungal medications. R…

This early-stage study tested APX001, a potential new oral medication for fungal infections, in healthy volunteers. The main goal was to check if the drug is safe and to understand how the body absorbs and processes it. Researchers also looked at whether food affects the drug and…

This was the first study in humans to test the safety and how the body processes a new drug called VNRX-7145. It involved 83 healthy adult volunteers who received either the drug or a placebo. The main goal was to see if the drug was safe and to measure how long it stayed in the …

This early-stage study tested how two new drugs, VNRX-7145 and VNRX-5024, interact when taken together and measured their safety in healthy adults. The goal was to understand how the body processes these drugs and what side effects might occur. This information helps researchers …

This was the first study to test APX001 in people. Researchers gave the experimental drug to 80 healthy volunteers to check if it was safe and to see how the body processes it. The goal was to gather basic safety information before testing it in people who actually have fungal in…

This early-stage study aimed to check the safety and see how the body absorbs and processes an experimental drug called VNRX-5024. It involved 36 healthy adult volunteers who took either the drug or a placebo for up to 10 days. The main goal was to find a safe dose range and unde…

This study aimed to understand how a new antibiotic combination is processed by the body in people with varying levels of kidney function. It involved 32 adults, some with healthy kidneys and others with mild to severe kidney problems. Researchers gave a single dose and measured …

This was an early-stage study to understand how a new drug called fosmanogepix is processed by the body and to check its safety. It involved 54 healthy Chinese adults who received either the drug or a placebo, given as a single dose or multiple doses, either by mouth or through a…

This early-stage study aimed to understand how a single dose of the experimental drug fosmanogepix is processed by the body in people with different levels of liver function. It involved 28 adults, some with healthy livers and some with mild to severe liver impairment. The main g…

This study tested how eating food affects how the body absorbs and processes an experimental antibiotic combination called Ceftibuten/VNRX-7145. It involved healthy adult volunteers who took the drug once while fasting and once after a meal. The goal was to understand if food cha…

This early-stage study aimed to understand how two experimental antibiotics, ceftibuten and ledaborbactam, move from the blood into the lungs after people take them by mouth. Researchers gave the drugs to 34 healthy adults and collected samples from their blood and lung fluid to …