Basilea Pharmaceutica

This study tested an experimental drug called APX001 in 21 adults with Candida bloodstream infections, including cases where standard antifungals might not work. Participants received the drug for up to 14 days, with possible follow-up treatment. The goal was to see if the drug c…

This Phase 2 trial tested an experimental antifungal drug called APX001 (fosmanogepix) in 9 adults with blood or deep-organ infections caused by Candida auris, a fungus that often resists standard treatments. The drug was given by IV or mouth for up to 42 days. The goal was to se…

This early-stage trial tested the safety and tolerability of a new antifungal drug called APX001 in 200 healthy volunteers. Participants received either single or multiple doses of the drug or a placebo. The study focused on side effects and how the drug moves through the body, n…

This completed phase 1 study looked at whether the antibiotic ceftobiprole changes how the body handles the cholesterol drug pitavastatin. Twelve healthy adults received pitavastatin alone and then with ceftobiprole to compare drug levels in the blood. The goal is to see if combi…

This completed Phase 1 trial studied the safety and how the body handles the experimental antifungal drug fosmanogepix in 54 healthy Chinese adults. Participants received single or multiple doses of the drug either by mouth or through an IV, or a placebo. The study measured drug …

This completed Phase 1 study tested how two antibiotics, ceftibuten and ledaborbactam, move through the blood and lungs of 34 healthy adults aged 18-55. Participants took five doses of the drugs and underwent a bronchoscopy to measure drug levels in lung fluid. The goal was to un…

This study looked at how a single dose of the antifungal drug fosmanogepix is processed in the bodies of 28 adults with varying degrees of liver impairment. Participants took one pill by mouth, and researchers measured drug levels in the blood over time. The goal was to see if li…

This early-stage study tested how a single dose of the antibiotic combination ceftibuten/VNRX-7145 is processed by the body in 32 adults with normal or impaired kidney function, including those on dialysis. Researchers measured drug levels in the blood and monitored safety. The g…

This study looked at how safe two experimental antibiotics (VNRX-7145 and ceftibuten) are when given alone or together. It involved 53 healthy adults aged 18 to 55. The goal was to measure how the drugs move through the body and check for side effects, not to treat any illness.

This study tested whether taking a new antibiotic (ceftibuten/VNRX-7145) with food changes how the body absorbs it. Twenty-four healthy adults took the drug once while fasting and once after a meal. Researchers measured drug levels in the blood to see if food affects safety or ef…

This early-stage study tested the safety of a new drug called VNRX-5024 in 36 healthy adults aged 18-55. Participants received either the drug or a placebo, first as a single dose and then daily for 10 days. The main goal was to check for side effects and measure how the drug mov…

This early-stage trial tested the safety of a new drug, VNRX-7145, in 83 healthy adults aged 18 to 45. Participants received either a single dose or multiple doses over 10 days to see how the body handles the drug and if any side effects occur. The study is complete and focused o…

This Phase 1 trial tested the safety and tolerability of a new antifungal drug called APX001 in 46 healthy volunteers. Researchers gave single and multiple doses, both orally and intravenously, to see how the body handles the drug and whether food affects it. The study also looke…