UVEAL MELANOMA

This study is testing whether an experimental oral medication called roginolisib can help people with advanced uveal (eye) melanoma live longer than standard treatments. About 85 adults who have already tried at least one immunotherapy will receive either roginolisib or their doc…

This study is testing whether a drug called IDE196 (darovasertib) can help control eye melanoma when given before and sometimes after standard treatments like radiation or eye removal. Researchers want to see if the drug shrinks tumors enough to avoid removing the eye, reduces ra…

This study is testing whether eating a high-fiber diet can improve gut health and help the immune system fight cancer in patients with advanced melanoma who are receiving standard immunotherapy. Fifty participants will be randomly assigned to follow either a high-fiber diet or a …

This early-stage study is testing a personalized treatment called TBio-4101 for people with advanced melanoma that hasn't responded to standard therapies. Doctors take immune cells from a patient's tumor, grow them in large numbers in a lab, and then infuse them back into the pat…

This study is testing a new approach for treating large eye tumors (choroidal melanoma) to try to save the eye from removal. Researchers want to see if injecting a chemotherapy drug directly into the artery feeding the tumor can shrink it enough to allow a follow-up radiation tre…

This study is testing whether watching educational videos can help people who have survived a rare eye cancer called uveal melanoma. The goal is to see if changing how patients think about their illness can reduce feelings of anxiety and depression during survivorship. About 108 …

This study is screening cancer patients to collect genetic information from their tumors and saliva. Researchers will analyze this data to identify patients who might qualify for future clinical trials testing new cellular therapies. No treatment is provided in this study—it's pu…

This study aims to discover new inherited genes that increase the risk of uveal melanoma, a rare cancer of the eye. Researchers will analyze the complete genetic code of 50 patients with this cancer to look for shared, rare changes that might explain why it sometimes runs in fami…