UVEAL MELANOMA
Clinical trials for UVEAL MELANOMA explained in plain language.
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Experimental vaccine aims to stop rare eye cancer from returning
⭐️ VACCINE ⭐️ CompletedThis phase 3 trial tested a personalized vaccine made from a patient's own immune cells and tumor RNA in 200 people with a high-risk form of eye cancer (uveal melanoma with monosomy 3). After surgery to remove the tumor, half received the vaccine over two years and half were simp…
Matched conditions: UVEAL MELANOMA
Phase: PHASE3 • Sponsor: University Hospital Erlangen • Aim: ⭐️ VACCINE ⭐️
Last updated Jun 27, 2026 09:00 UTC
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New drug shows promise in shrinking eye cancer before surgery
Disease control CompletedThis phase 2 trial tested the drug darovasertib in 15 people with high-risk uveal melanoma (a rare eye cancer) who were scheduled for eye removal surgery. Participants took the drug for up to 4 weeks before surgery, and some continued for 6 months afterward. The main goals were t…
Matched conditions: UVEAL MELANOMA
Phase: PHASE2 • Sponsor: St Vincent's Hospital, Sydney • Aim: Disease control
Last updated Jun 27, 2026 12:23 UTC
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Supercharged immune cells take on tough melanoma
Disease control CompletedThis early-phase trial tested a new personalized therapy called TBio-4101 for people with advanced melanoma that had stopped responding to standard treatments. The therapy uses a patient's own tumor-fighting immune cells, which are collected, multiplied in the lab, and then infus…
Matched conditions: UVEAL MELANOMA
Phase: PHASE1 • Sponsor: H. Lee Moffitt Cancer Center and Research Institute • Aim: Disease control
Last updated Jun 27, 2026 12:03 UTC
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New hope for rare eye cancer: IMCgp100 shows promise in advanced uveal melanoma trial
Disease control CompletedThis study tested a new drug called IMCgp100 in 378 adults with a specific genetic type (HLA-A*0201) of advanced uveal melanoma, a rare eye cancer. Participants received either IMCgp100 or one of three standard treatments (dacarbazine, ipilimumab, or pembrolizumab). The main goal…
Matched conditions: UVEAL MELANOMA
Phase: PHASE2 • Sponsor: Immunocore Ltd • Aim: Disease control
Last updated Jun 27, 2026 11:02 UTC
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Can a liver cancer drug stop eye cancer spread?
Disease control CompletedThis study tested the drug sorafenib (Nexavar) in 32 adults with uveal melanoma that had spread to other parts of the body. The goal was to see if the drug could stop tumors from growing for at least 24 weeks. Sorafenib is already used for other cancers, and researchers wanted to…
Matched conditions: UVEAL MELANOMA
Phase: PHASE2 • Sponsor: University Hospital, Caen • Aim: Disease control
Last updated Jun 27, 2026 09:06 UTC
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Can early supportive care ease the emotional toll of advanced eye cancer?
Symptom relief CompletedThis study looked at whether starting supportive care early, alongside standard cancer treatment, helps patients with metastatic uveal melanoma feel more supported. 162 adults with advanced eye cancer that had spread were randomly assigned to get either standard oncology visits o…
Matched conditions: UVEAL MELANOMA
Phase: NA • Sponsor: Institut Curie • Aim: Symptom relief
Last updated Jun 26, 2026 14:26 UTC
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Scientists decode DNA of rare eye tumors to track Cancer's moves
Knowledge-focused CompletedThis study looked at the DNA changes (mutations) in eye cancers called ocular melanoma. Researchers analyzed tumor samples from 58 patients to understand how these cancers develop and spread. The goal was to identify key mutations that could lead to better treatments in the futur…
Matched conditions: UVEAL MELANOMA
Sponsor: The Wellcome Sanger Institute • Aim: Knowledge-focused
Last updated Jun 27, 2026 12:02 UTC
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Blood test may predict success of liver surgery for rare eye cancer
Knowledge-focused CompletedThis study looked at whether measuring tumor DNA in the blood can help doctors know if surgery to remove liver metastases from uveal melanoma was successful. Researchers took blood samples from 60 patients before and after surgery and during follow-up. The goal was to see if chan…
Matched conditions: UVEAL MELANOMA
Phase: NA • Sponsor: Institut Curie • Aim: Knowledge-focused
Last updated Jun 26, 2026 19:05 UTC