New eye injection could spare sight in melanoma patients

NCT ID NCT06007690

Ongoing Disease control Sponsor: Aura Biosciences Source: ClinicalTrials.gov ↗

First seen Jun 26, 2026 · Last updated Jul 31, 2026 · Updated 2 times

Summary

This Phase 3 trial tests a new drug called belzupacap sarotalocan (AU-011) for people with small choroidal melanoma or suspicious spots in the eye. The drug is injected into the eye and activated by a laser to target cancer cells. The study compares it to a sham (fake) procedure to see if it safely stops tumor growth and preserves vision. About 100 participants will be enrolled.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: belzupacap sarotalocan (AU-011) given as an injection into the eye followed by laser activation
What this could lead to: If successful, this could offer a new eye-sparing treatment option for small choroidal melanoma, potentially delaying or avoiding the need for more aggressive therapies like radiation or enucleation.
What could go wrong: This is an early Phase 3 trial with only 100 participants, so results may not apply to all patients. The treatment involves eye injections and laser, which carry risks like infection, inflammation, or vision changes.

This is an AI summary of the original study and may miss details. Read our disclaimer.

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Conditions

The condition(s) this trial relates to.

malignant choroid melanoma ocular cancer ocular melanoma small size posterior uveal melanoma uveal melanoma

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

CHOROIDAL MELANOMA INDETERMINATE LESIONS OCULAR MELANOMA UVEAL MELANOMA

Contacts and locations

Locations

AOUC Azienda Ospedaliero-Universitaria Careggi

Florence, 50134, Italy
Associated Retinal Consultants (ARC) P.C.

Royal Oak, Michigan, 48073, United States
Auckland Eye Ltd

Auckland, 1050, New Zealand
Austin Retina Associates

Austin, Texas, 78705, United States
Centre Hospitalier Universitaire de Nice

Nice, Cedex 1, 06001, France
Centre Hospitalier de l'Universite Laval

Québec, Quebec, G1S 4L8, Canada
Charité - Universitätsmedizin Berlin KöR

Berlin, 12203, Germany
Cliniques universitaires Saint-Luc

Brussels, Belgium
Cole Eye Institute

Cleveland, Ohio, 44195, United States
Columbia University Irving Medical Center

New York, New York, 10032, United States
Dean McGee Eye Institute

Oklahoma City, Oklahoma, 73104, United States
Doris Stein Eye Research Center

Los Angeles, California, 90095, United States
Emory Eye Center

Atlanta, Georgia, 30322, United States
Erasmus MC

Rotterdam, 3015AA, Netherlands
Eye Research Australia

East Melbourne, Victoria, 3002, Australia
Fakultni Thomayerova nemocnice

Prague, Krč, 14059, Czechia
Fakultni nemocnice Plzen

Pilsen, Plzenský Kraj, 32300, Czechia
Hadassah Medical Center, Ein-Karem

Jerusalem, Jerusalem, 9112001, Israel
Hospices Civils de Lyon - Hôpital de La Croix Rousse - Hospital

Lyon, Rhone, 69004, France
Hospital Provincial de Conxo

Santiago de Compostela, 15706, Spain
Hospital Universitario Y Politécnico La Fe

Valencia, 46026, Spain
Hospital Universitario de Bellvitge

Barcelona, 08907, Spain
Hospital Virgen Macarena

Seville, 41009, Spain
Istituto Nazionale dei Tumori, Fondazione IRCCS

Milan, 20133, Italy
Klinikum der LMU Muenchen

München, 80336, Germany
Leids Universitair Medisch Centrum (LUMC)

Leiden, 2333 ZE, Netherlands
Massachusetts Eye and Ear

Boston, Massachusetts, 02114, United States
Mayo Clinic

Rochester, Minnesota, 55905, United States
Medical University Graz

Graz, 8036, Austria
Medizinische Universität Wien, Department of Ophthalmology and Optometry

Vienna, 1090, Austria
Moorfields Eye Hospital NHS Foundation Trust

London, EC1V 2PD, United Kingdom
Nebraska Medicine's Truhlsen Eye Institute

Omaha, Nebraska, 68105, United States
Nhs Foundation Trust - Royal Hallamshire Hospital

Sheffield, S10 2JF, United Kingdom
Ospedale Fatebenefratelli e Oftalmico, ASST Fatebenefratelli Sacco

Milan, 20157, Italy
Pacific NW Retina

Burlington, Washington, 98233, United States
Retina Associates of Florida, PA

Tampa, Florida, 33609, United States
Retina Associates of South Texas, P.A.

San Antonio, Texas, 78240, United States
Retina Associates of Utah

Salt Lake City, Utah, 84107, United States
Retina Center of Texas

Southlake, Texas, 76092, United States
Retina Consultants of Carolina

Greenville, South Carolina, 29605, United States
Retina Consultants of Oklahoma

Oklahoma City, Oklahoma, 73112, United States
Retina Consultants of Texas

The Woodlands, Texas, 77401, United States
Retinal Consultants Medical Group, Inc.

Sacramento, California, 95825, United States
Serac Eye and Skin Care Centre

Calgary, Alberta, T2V 4Y8, Canada
Shields & Shields PC-Wills Eye Institute

Philadelphia, Pennsylvania, 19107, United States
Southeastern Retina Associates

Chattanooga, Tennessee, 37421, United States
Stanford University School of Medicine

Palo Alto, California, 94303, United States
Tennessee Retina, PC

Nashville, Tennessee, 37203, United States
Texas Retina Associates

Dallas, Texas, 75231, United States
The Chaim Sheba Medical Center

Tel-Hashomer, Central District, 5262100, Israel
Tufts Medical Center New England Eye Center

Boston, Massachusetts, 02111, United States
UCSD Shiley Eye Institute, Jacobs Retina Center

La Jolla, California, 92093, United States
UZ Leuven

Leuven, 3000, Belgium
Uniklinikum Hamburg Eppendorf

Hamburg, 20246, Germany
Universita'Cattolica Del Sacro Cuore - UNICATT

Roma, 00168, Italy
University Hospital Cologne (AöR)

Cologne, 50937, Germany
University of Illinois at Chicago

Chicago, Illinois, 60612, United States
University of Washington Medical Center

Seattle, Washington, 98104, United States
University of Wisconsin Madison

Madison, Wisconsin, 53705, United States
Universitätsklinikum Schleswig-Holstein Klinik für Augenheilkunde

Lübeck, 23538, Germany
Universitätsklinikum Tübingen

Tübingen, 72076, Germany
Universitätsmedizin Essen

Essen, 45147, Germany
Ustredni vojenska nemocnice Vojenska fakultni nemocnice Praha

Prague, 16902, Czechia
Vitreoretinal Associates of Washington

Bellevue, Washington, 98004, United States
W.K. Kellogg Eye Center - University of Michigan

Ann Arbor, Michigan, 48105, United States
Washington University

St Louis, Missouri, 63110, United States

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