URETERAL CALCULI

This study tests a new device called the Enhanced Lithotripsy System (ELS) that uses low-pressure ultrasound to activate tiny bubbles in the urine, breaking kidney or ureter stones into small pieces that can pass naturally. The trial will enroll 101 adults with a single stone in …

This study tests a new technique called Burst Wave Lithotripsy (BWL) that uses bursts of low-amplitude ultrasound to break kidney stones into tiny pieces during a standard surgical procedure. About 40 adults scheduled for stone removal will receive BWL to see if it is safe and ef…

This study tests two medications, mirabegron and tamsulosin, to see which works best for helping people pass ureteral stones and reducing pain. 500 adults with stones between 4-10 mm will be randomly assigned to one of four groups: mirabegron alone, tamsulosin alone, both drugs t…

This study compares a new type of ureteral stent (ComfiJ) with a standard Double-J stent in 150 adults who need a short-term stent after kidney stone surgery. The goal is to see if the ComfiJ stent causes fewer urinary symptoms, like pain or urgency, two weeks after surgery. Part…

This study tests whether putting a drug called aminophylline into the bladder before placing a ureteral stent helps doctors get the stent past a blocking stone more easily. The trial involves 72 adults with sudden kidney failure from stones in a single working kidney. Half get th…

This study compares L-citrulline, an amino acid, to tamsulosin, a standard drug, for helping adults pass kidney stones. 120 people with a single stone in the lower ureter will take one of the two treatments for up to 4 weeks. The main goal is to see which treatment leads to faste…

This study tests if a drug called aminophylline, placed directly into the bladder, can help doctors insert a small scope to remove kidney stones in children. About 60 children aged 2 to 17 with a stone in the lower ureter will take part. If the first gentle attempt to pass the sc…

This study compares melatonin, solifenacin, and their combination to reduce bothersome urinary symptoms and pain caused by a temporary ureteral stent placed after kidney stone surgery. About 189 adults will take one of the two drugs or both for 14 days. The goal is to see which a…

This study is looking for factors that might predict inflammatory polyps in the ureter (the tube from kidney to bladder) in people with kidney stones. Researchers will review past patient data and then test their predictions on new patients. The goal is to create a simple tool th…

This large observational study will follow 4,000 adults undergoing percutaneous nephrolithotomy (PCNL) for kidney stones across many international centers. Researchers will track which surgical techniques are used, how well they clear stones, and what complications occur. The goa…