TUBERCULOSIS, PULMONARY

This study tested whether a vaccine called H56:IC31 can prevent tuberculosis (TB) from coming back in people who have already been successfully treated for TB. About 831 HIV-negative adults in South Africa and Tanzania took part. Half got the vaccine, half got a placebo, and rese…

This study compared tuberculosis patients in Benin, who received food support, with those in Togo, who did not. Researchers tracked whether nutritional help reduced treatment failure, death, or relapse. The goal is to guide future TB programs on including nutrition as part of sta…

This study tested a new HIV medication (Biktarvy) taken twice daily in 122 adults who also have drug-sensitive tuberculosis (TB) and are on standard TB treatment. The main goal was to see if the drug could suppress HIV to undetectable levels by week 24. Results help doctors under…

This study tested a new immunotherapy called RUTI, given alongside standard antibiotics, for people with active lung tuberculosis. The goal was to see if it could help the immune system fight the bacteria more effectively and speed up recovery. 41 adults took part in this Phase 2…

This study tested two different doses of the drug linezolid, combined with three other medicines, to treat drug-resistant tuberculosis (TB). The goal was to see if a lower dose could work just as well but with fewer side effects. 138 adults with drug-resistant TB took part. The r…

This study tested a vaccine called RUTI as an extra treatment for people with tuberculosis (TB). 140 adults with drug-sensitive or drug-resistant TB received either the vaccine or a placebo along with their regular TB medicines. The goal was to see if the vaccine could help clear…

This study looked at whether a bronchoscopy (a thin, flexible tube with a camera) can help find tuberculosis (TB) in the airways of people whose standard sputum tests came back negative. 63 adults with suspected TB but negative sputum samples took part. The goal was to see if thi…

This study tested a new rapid blood test called SeroSelectTB to see if it can diagnose active tuberculosis (TB) faster than current methods. Over 9,000 adults in South Africa, Tanzania, and Ethiopia who had symptoms of TB or pneumonia took part. The goal was to see if using this …

This study looked at whether a supervised exercise program can improve heart and lung function and quality of life in people who have lasting health problems after tuberculosis. Sixty adults with a history of TB took part. They were split into two groups: one did the exercise pro…

This study looked at 141 adults with active lung tuberculosis to see if intestinal parasites or poor nutrition make TB harder to treat. Researchers checked stool samples for parasites and measured weight gain and treatment success. Some participants received nutritional supplemen…