TREATMENT

This study tests a personalized vaccine made from a patient's own immune cells (dendritic cells) that are trained to attack unique markers on their tumor. It is for people aged 18-75 with advanced solid tumors who have not responded to standard treatments. The goal is to see if t…

This study compares two antibody drugs, daratumumab and rituximab, in 160 adults with immune thrombocytopenia (ITP) whose condition did not improve or came back after steroid treatment. The main goal is to see which drug better raises platelet counts to safe levels by week 12 wit…

This study tests a new treatment using stem cells from amniotic membrane for people with calciphylaxis, a rare and painful condition where blood vessels harden and cause severe skin wounds. The treatment is given to 9 adults with chronic kidney disease to see if it helps wounds h…

This study tests a special laser (micropulse) to treat diabetic macular edema, a common cause of vision loss in people with diabetes. The trial will include 50 adults with diabetes who have central retinal swelling. Researchers will measure changes in vision and retinal thickness…

This study tests two different acid-reducing medicines (P-CAB and PPI) as part of a four-drug treatment for H. pylori, a stomach infection. About 320 adults who have not been treated before will take one of the two combinations. The goal is to see which approach kills the bacteri…

This study tests a combination of three drugs—venetoclax, ivosidenib, and azacitidine—in adults with acute myeloid leukemia (AML) that has an IDH1 mutation. The goal is to see if this triple therapy can improve remission rates and survival. About 23 participants will receive the …

This study tests whether replacing two standard chemotherapy drugs with brentuximab vedotin can help more children and young adults (ages 2 to 34) with newly diagnosed Hodgkin lymphoma achieve a complete response early in treatment. The goal is to reduce the need for radiation th…

This study tests whether a combination of Chinese herbs and intradermal acupuncture can help slow down or reverse early puberty in girls. About 170 girls diagnosed with idiopathic precocious puberty will receive either the treatment or a control. The main goal is to see if breast…

This study tests two types of special glasses designed to slow the progression of nearsightedness (myopia) in children aged 6 to 14. Participants will wear the glasses daily for one year and attend regular eye exams. The goal is to see which lens design works best and whether the…

This study compares two drugs, daratumumab and rituximab, in children aged 6 to 17 with immune thrombocytopenia (ITP) whose condition did not improve or came back after steroid treatment. ITP causes low platelet counts, leading to bruising and bleeding. The goal is to see which d…

This study tests a combination of two drugs, rituximab and daratumumab, in 20 adults with immune thrombocytopenia (ITP) who did not get better with steroids. The goal is to see if the combination can safely raise platelet counts and reduce bleeding. Participants will receive the …

This study tests a new drug (anti-CD38 antibody) in 60 children aged 6 and older with immune thrombocytopenia (ITP), a condition where the immune system destroys platelets, causing bleeding. The drug aims to raise platelet counts safely in kids who haven't improved with standard …

This study tests whether adding an anti-CD38 antibody to the standard drug rituximab works better than rituximab alone for adults with immune thrombocytopenia (ITP) whose platelet counts stayed low or came back after steroid treatment. About 160 participants will receive either t…

This study compares two surgical techniques for removing a uterine septum, a wall of tissue inside the uterus that can cause problems. Researchers want to see if using scissors without electricity is better than using an electric tool. The study will measure surgery time, costs, …

This study aims to improve quitting success for smokers who find it hard to stop with standard medications. About 544 participants will receive free nicotine patches, lozenges, varenicline, or e-cigarettes for 12 weeks, with treatment adjusted based on individual response. All vi…

This study is looking at what factors in a person's health history might affect how well a nerve block injection works for medication-overuse headache. Researchers will track 70 adults who get the injection and see how their headache days and pain levels change. The goal is to be…