TREATMENT

This study tested if injecting the antifungal drug fluconazole directly into the cornea is safe and effective for treating fungal keratitis, a serious eye infection. 40 patients with lab-confirmed fungal infections that were sensitive to fluconazole took part. The researchers mea…

This study compared clear mandibular advancement aligners to traditional twin-block braces for correcting Class II Division 1 malocclusion (overbite) in 21 children aged 10-16. Participants were split into three groups and followed for 6 months. The goal was to see if the aligner…

This phase 2 trial tested whether a new way of targeting radiation (based on where the cancer usually comes back) works better than the standard method for locally advanced pancreatic cancer. 96 patients received either the new or standard radiation. The study looked at how long …

This study looked at 119 people with locally advanced pancreatic cancer to see which radiation dose (lower or higher) works better when combined with chemotherapy. The goal was to find a dose that helps people live longer without causing too many side effects. Participants had no…

This study tested whether injecting platelet-rich plasma (a concentrated part of your own blood) into the surgical wound helps people recover better after pilonidal sinus surgery. Forty patients with chronic or recurrent pilonidal sinuses took part. The goal was to see if this ex…

This pilot study tested a short form of Acceptance and Commitment Therapy (ACT) in 49 people living with HIV who were hazardous drinkers. The therapy uses mindfulness and values-based action to reduce drinking and improve medication adherence. Researchers measured drinking days, …

This study tested two sleep medications (suvorexant and zolpidem) against a placebo in 40 adults with Progressive Supranuclear Palsy (PSP). The goal was to see if targeting the brain's wake-promoting system could improve sleep quality and daytime well-being. Each person tried all…

This completed trial tested whether an injection made from a patient's own blood (platelet-rich fibrin) can improve pain and jaw opening in people with temporomandibular joint (TMJ) disorders. Forty adults were randomly assigned to receive either standard joint washing alone or j…

This study tested two techniques for washing out the jaw joint (arthrocentesis) in 30 adults with TMJ disorders. One method used a single needle, the other a catheter. Researchers measured pain and how wide patients could open their mouths. The goal was to see which approach prov…

This study followed 250 chronic hepatitis B patients over age 30 who had detectable virus but normal liver enzyme levels (ALT). All had never received antiviral treatment before. Researchers measured how many became virus-negative after 48 weeks of antiviral therapy, and how many…

This study looked at how migraine patients and healthcare providers in Thailand experience eptinezumab, a preventive migraine infusion given every 3 months. Researchers interviewed 30 participants to find out what makes it easier or harder to use this treatment in a real-world ho…

This study looked at 87 people with frozen shoulder to see if their level of central sensitization—a condition where the nervous system is extra sensitive to pain—affected how well they responded to a shoulder injection. Researchers measured central sensitization using a question…