SURGICAL SITE INFECTION (SSI)

This study tests a special vacuum dressing (ciNPWT) placed over the surgical incision to prevent wound infections and healing problems in women at high risk after gynecologic cancer surgery. Thirty participants will receive either the device or standard dressing after planned abd…

This study tests whether a new DNA test called Next Generation Sequencing (NGS) can help doctors better treat infections that happen after bone fracture surgery. About 250 adults with deep infections after fracture repair will be randomly assigned to get treatment based on standa…

This study compares two common stitch materials—absorbable Vicryl and non-absorbable Prolene—for closing the abdominal wall after surgery. Researchers will track 156 patients in Pakistan for 6 months to see which suture leads to fewer hernias, infections, and less pain. The goal …

This study tests whether rinsing the surgical wound with a solution called PREVENTIA (polyhexanide and poloxamer) during spinal fusion surgery can reduce bacteria in the wound. About 114 adults having elective spine surgery will be randomly assigned to receive either the special …

This study compares two ways of giving the antibiotic cefazolin during coronary artery bypass surgery to prevent wound infections. One group gets the drug as a steady drip (continuous infusion), the other as standard short injections. The trial will enroll 100 adults in Egypt and…

This study compares two methods of giving the antibiotic cefazolin during orthopedic surgery to prevent surgical site infections. One group receives a continuous infusion during surgery, while the other gets the standard single dose before surgery. The trial will enroll 100 adult…

This study tests a safety bundle—staff training, checklists, and audits—to prevent surgical site infections after emergency C-sections and open leg fracture repairs in Ethiopia. About 1,000 patients at public hospitals will be followed for 2 years to measure infection rates and d…

This study tests whether applying vancomycin powder directly into the surgical wound during shunt placement can prevent infections in children with hydrocephalus. About 164 children will be randomly assigned to receive either standard care or standard care plus the powder. The go…

This study tests whether keeping blood sugar tightly controlled after brain surgery can reduce surgical site infections. About 544 adults having elective clean brain surgery will be randomly assigned to either intensive insulin therapy (target 140-180 mg/dL) or standard care (81-…

This study looks at whether getting a surgical wound wet within 48 hours after skin surgery is safe compared to waiting 7 days. About 82 adults having minor skin procedures will be randomly assigned to early or delayed water exposure. Doctors will check for infections using a sta…