New DNA test could slash infection failures after broken bone surgery

NCT ID NCT07458230

Not yet recruiting Disease control Sponsor: Johns Hopkins Bloomberg School of Public Health Source: ClinicalTrials.gov ↗

First seen Jun 27, 2026 · Last updated Jul 10, 2026 · Updated 2 times

Summary

This study tests whether a new DNA test called Next Generation Sequencing (NGS) can help doctors better treat infections that happen after bone fracture surgery. About 250 adults with deep infections after fracture repair will be randomly assigned to get treatment based on standard tests or standard tests plus NGS. The goal is to see if NGS reduces the need for additional surgeries and improves recovery.

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Conditions

The condition(s) this trial relates to.

Surgical Wound Infection

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

FRACTURE FIXATION NEXT GENERATION SEQUENCING (NGS) SURGICAL SITE INFECTION (SSI)

Contacts and locations

Locations

Carolinas Medical Center

Charlotte, North Carolina, 28203, United States
Dartmouth Hitchcock Medical Center

Lebanon, New Hampshire, 03766, United States
Inova Fairfax Medical Campus

Fairfax, Virginia, 22042, United States
Loyola University Medical Center

Maywood, Illinois, 60153, United States
McGovern Medical School at UTHealth Houston

Houston, Texas, 77030, United States
Methodist Hospital

Indianapolis, Indiana, 46202, United States
Ohio State University Hospital

Columbus, Ohio, 43210, United States
R Adams Cowley Shock Trauma Center

Baltimore, Maryland, 21201, United States
UCSF Medical Center

San Francisco, California, 94143, United States
UVA Health University Medical Center

Charlottesville, Virginia, 22908, United States
UW Health University Hospital

Madison, Wisconsin, 53792, United States
University of Alabama

Tuscaloosa, Alabama, 35487, United States
University of Mississippi Medical Center

Jackson, Mississippi, 39216, United States
University of Pennsylvania

Philadelphia, Pennsylvania, 19104, United States
University of Southern California

Los Angeles, California, 90007, United States
University of Utah Hospital

Salt Lake City, Utah, 84132, United States
Vanderbilt University Medical Center

Nashville, Tennessee, 37232, United States
Warren Alpert Medical School of Brown University

Providence, Rhode Island, 02903, United States

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