New DNA test could slash infection failures after broken bone surgery
NCT ID NCT07458230
First seen Mar 14, 2026 · Last updated May 01, 2026 · Updated 9 times
Summary
This study tests whether a new DNA test called Next Generation Sequencing (NGS) can improve treatment for infections that occur after surgery to fix broken bones. About 250 adults with deep infections after fracture surgery will be randomly assigned to get treatment guided by either standard lab cultures or both cultures and NGS. The goal is to see if NGS helps reduce the need for repeat surgeries and leads to better antibiotic choices.
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This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
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Study contacts
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Locations
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Carolinas Medical Center
Charlotte, North Carolina, 28203, United States
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Dartmouth Hitchcock Medical Center
Lebanon, New Hampshire, 03766, United States
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Inova Fairfax Medical Campus
Fairfax, Virginia, 22042, United States
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Loyola University Medical Center
Maywood, Illinois, 60153, United States
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McGovern Medical School at UTHealth Houston
Houston, Texas, 77030, United States
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Methodist Hospital
Indianapolis, Indiana, 46202, United States
Contact Phone: •••-•••-•••• Email: •••••@•••••
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Ohio State University Hospital
Columbus, Ohio, 43210, United States
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R Adams Cowley Shock Trauma Center
Baltimore, Maryland, 21201, United States
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UCSF Medical Center
San Francisco, California, 94143, United States
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UVA Health University Medical Center
Charlottesville, Virginia, 22908, United States
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UW Health University Hospital
Madison, Wisconsin, 53792, United States
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University of Alabama
Tuscaloosa, Alabama, 35487, United States
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University of Mississippi Medical Center
Jackson, Mississippi, 39216, United States
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University of Pennsylvania
Philadelphia, Pennsylvania, 19104, United States
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University of Southern California
Los Angeles, California, 90007, United States
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University of Utah Hospital
Salt Lake City, Utah, 84132, United States
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Vanderbilt University Medical Center
Nashville, Tennessee, 37232, United States
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Warren Alpert Medical School of Brown University
Providence, Rhode Island, 02903, United States
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Conditions
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