STAGE IVB LUNG CANCER AJCC V8

This study tests a drug called avapritinib in people with advanced solid tumors that have spread and have specific gene changes (CKIT or PDGFRA mutations). The drug works by blocking enzymes that help cancer cells grow. The goal is to see if avapritinib can shrink or control thes…

This early-phase study tests a combination of two drugs, osimertinib and tegavivint, as the first treatment for people with a certain type of advanced lung cancer that has spread. The goal is to find the safest dose and see if the combination helps shrink tumors. About 24 adults …

This study tests a combination of chemotherapy (temozolomide) and immunotherapy (atezolizumab) for people with small cell lung cancer that has spread or returned after initial treatment. The goal is to see if this combo can shrink tumors and help patients live longer. About 56 ad…

This study tests a personalized vaccine made from a patient's own tumor proteins, combined with the immunotherapy drug pembrolizumab, for people with advanced solid tumors. The goal is to see if this combination is safe and helps the immune system fight cancer more effectively. A…

This study tests a new drug (MRX-2843) combined with a standard treatment (osimertinib) in people with advanced EGFR-mutant non-small cell lung cancer. The goal is to find the safest dose and see how well the combination works. About 69 participants will take part in this early-p…

This early-phase trial tests a new drug (PBF-1129) combined with an existing immunotherapy (nivolumab) in 30 adults with advanced non-small cell lung cancer that has returned or spread. The main goal is to find the safest dose and understand side effects. Researchers also want to…

This early study tests whether adding low-dose IL-2 to the immunotherapy drug pembrolizumab can better activate the immune system against stage IV non-small cell lung cancer. About 15 people with untreated advanced lung cancer will receive the combination. The goal is to see if t…

This study tests a special dye that attaches to lung cancer cells and makes them glow under a special camera during surgery. The goal is to help surgeons see and remove all cancer tissue more accurately. About 30 adults with lung cancer or lung metastases will receive the dye bef…

This study tests a method called adaptive radiation planning for people with stage II to IV non-small cell lung cancer. Normally, radiation plans stay the same throughout treatment, but tumors can shrink, causing radiation to hit healthy tissue. By updating the plan at set times,…

This study tests whether a yoga program designed for both patients and their family caregivers can improve physical function, fatigue, sleep, and quality of life. It includes 400 people with lung or esophageal cancer who are getting radiation therapy, plus their caregivers. Parti…

This study looks at how the bacteria in your gut might cause stomach issues like diarrhea and colitis when you take certain cancer drugs called immune checkpoint inhibitors. Researchers will collect stool, blood, and tissue samples from 800 people with melanoma, lung, or genitour…