New combo aims to extend life in tough lung cancer

NCT ID NCT04919382

Recruiting now Disease control Sponsor: Dwight Owen Source: ClinicalTrials.gov ↗

First seen Jun 25, 2026 · Last updated Jun 27, 2026 · Updated 1 time

Summary

This phase II trial tests whether combining the chemotherapy drug temozolomide with the immunotherapy atezolizumab can shrink tumors or prolong survival in people with advanced small cell lung cancer that has spread or returned. About 56 participants who have already had one or two prior treatments will receive the drug combination. The main goal is to see how many patients respond to treatment.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: temozolomide and atezolizumab
What this could lead to: If successful, this combination could offer a new treatment option to help people with advanced small cell lung cancer live longer.
What could go wrong: This is an early-phase trial with only 56 participants, so results may not apply to everyone. The drugs can cause side effects like fatigue, nausea, and immune-related reactions.

This is an AI summary of the original study and may miss details. Read our disclaimer.

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Conditions

The condition(s) this trial relates to.

lung cancer lung neoplasm small cell lung carcinoma

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

EXTENSIVE STAGE LUNG SMALL CELL CARCINOMA METASTATIC LUNG SMALL CELL CARCINOMA RECURRENT LUNG SMALL CELL CARCINOMA STAGE IV LUNG CANCER AJCC V8 STAGE IVA LUNG CANCER AJCC V8 STAGE IVB LUNG CANCER AJCC V8

Contacts and locations

Locations

Indiana University Melvin and Bren Simon Comprehensive Cancer Center
RECRUITING

Indianapolis, Indiana, 46202, United States
Ohio State University Comprehensive Cancer Center
RECRUITING

Columbus, Ohio, 43210, United States
University of Illinois Cancer Center
RECRUITING

Chicago, Illinois, 60612, United States
University of Iowa Hospitals and Clinics
RECRUITING

Iowa City, Iowa, 52242, United States
University of Wisconsin
RECRUITING

Madison, Wisconsin, 53705, United States

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