STAGE II PROSTATE CANCER AJCC V8

This study tests whether a very low dose of apalutamide, a drug that blocks testosterone, can lower PSA levels in men with early-stage prostate cancer who are about to have their prostate removed. About 34 men will take the drug for 3-4 weeks before surgery. If PSA drops enough, …

This study tests whether a shorter, higher-dose radiation schedule (hypofractionated) works as well as the standard longer course for prostate cancer patients who have had their prostate removed. About 186 men with stage I to IVA prostate cancer will be randomly assigned to one o…

This study aimed to see if adding the immunotherapy drug pembrolizumab to standard hormone therapy and radiation could improve outcomes for men with high-risk prostate cancer that hasn't spread. It was designed for adults with newly diagnosed, localized disease. However, the stud…

This study tests whether adding a procedure called vesicopexy (which repositions the bladder) to standard robotic prostate surgery helps men recover bladder control faster. About 196 men with early-stage prostate cancer will be randomly assigned to get surgery with or without ves…

This study compares two types of radiation therapy for men with early-stage prostate cancer that hasn't spread. One method places a radioactive seed directly into the prostate for a few minutes, while the other delivers radiation from outside the body in five sessions. The goal i…

This study tests a program called Watchful Living for Black and Hispanic men with early-stage prostate cancer and their partners. The program includes coaching calls and nutrition sessions to help improve quality of life, physical activity, and diet. The goal is to see if this su…

This study tests a lifestyle program for African American men who have finished prostate cancer treatment and their spouses or partners. The goal is to see if the program helps improve quality of life, partner support, physical activity, and diet. Only 6 couples are taking part, …

This study looks at how day-to-day stress and social support influence healthy behaviors like exercise and diet in Black prostate cancer survivors and their partners. About 200 couples will use a smartphone app to report their activities and feelings throughout the day. The goal …

This study looks at whether a DNA-based biomarker can help predict long-term urinary side effects from radiation therapy in men with prostate cancer. About 208 patients will have their DNA tested and both they and their doctors will see the results. The goal is to see if knowing …

This study looks at how hormone therapy for prostate cancer can affect the heart. Researchers are comparing two drugs, leuprolide and relugolix, to see which one is safer for the heart. About 94 men with non-spreading prostate cancer will take part. The goal is to find better way…

This study tested whether men with intermediate-risk prostate cancer could follow a Mediterranean diet before their surgery. The goal was to see if this approach is practical and well-tolerated. Twelve participants were enrolled, and researchers will use the results to understand…