STAGE II LUNG CANCER AJCC V8

This study tests whether giving two immunotherapy drugs (cemiplimab and fianlimab) before surgery can kill more tumor cells in people with stage IB to IIIB non-small cell lung cancer. About 60 adults will receive the drug combination before their tumor is removed. The goal is to …

This study tests whether adding the immunotherapy drug pembrolizumab to standard chemotherapy after lung cancer surgery helps people with stage II to IIIB non-small cell lung cancer live longer without the cancer coming back. About 1,210 participants will receive either the combi…

This study tests whether giving the immunotherapy drug durvalumab after surgery can help prevent early-stage non-small cell lung cancer from returning. About 306 people who have had their lung cancer completely removed will either receive durvalumab or be watched closely with no …

This study looks at whether giving chemotherapy and immunotherapy both before and after surgery is better than giving it only after surgery for people with stage II to IIIB non-small cell lung cancer that can be removed. About 1,100 adults will be randomly assigned to one of the …

This study tests whether artificial intelligence (AI) can help doctors choose the right radiation dose for lung tumors. About 70 people with lung cancer or tumors that spread to the lung will receive precise, high-dose radiation (SBRT) with doses guided by an AI tool. The goal is…

This study tests whether the drug canakinumab can prevent lung cancer in 50 people who have suspicious lung nodules that haven't gone away. Participants receive the drug and are monitored for nodule shrinkage, cancer development, and side effects. The goal is to see if this appro…

This study tests whether a home-based breathing exercise program can reduce shortness of breath, fatigue, and improve quality of life for people who have had surgery for early-stage lung cancer. About 100 survivors will be asked to do breathing exercises regularly for several wee…

This study tests a method called adaptive radiation planning for people with stage II to IV non-small cell lung cancer. Normally, radiation plans stay the same throughout treatment, but tumors can shrink, causing radiation to hit healthy tissue. By updating the plan at set times,…

This study tests whether doing special breathing exercises for several weeks before lung cancer surgery can lower the risk of problems like pneumonia and breathing trouble after the operation. About 220 adults with stage I to IIIB lung cancer will either do the exercises or recei…

This study tests whether a yoga program designed for both patients and their family caregivers can improve physical function, fatigue, sleep, and quality of life. It includes 400 people with lung or esophageal cancer who are getting radiation therapy, plus their caregivers. Parti…

This study looks at two standard surgical techniques for removing early-stage lung cancer: tying off the vein first versus the artery first. The goal is to see which method better reduces the amount of tumor DNA that gets into the bloodstream during surgery. About 100 adults with…

This study looks at whether giving early-stage lung cancer patients information about quality of life outcomes helps them feel more satisfied with their choice between surgery and radiation therapy. About 150 adults with stage I or II lung cancer who are eligible for both treatme…

This study looks at how the bacteria in your gut might cause stomach issues like diarrhea and colitis when you take certain cancer drugs called immune checkpoint inhibitors. Researchers will collect stool, blood, and tissue samples from 800 people with melanoma, lung, or genitour…

This study is testing whether a special communication tool helps doctors and lung cancer patients make treatment decisions together more effectively. The tool guides conversations about treatment options, benefits, and risks while considering each patient's personal situation and…