STAGE I PROSTATE CANCER AJCC V8

This study tests whether high-dose vitamin D can prevent bone loss caused by hormone therapy (ADT) in older men with prostate cancer. About 240 men aged 50+ who are starting or recently started ADT will take either high-dose vitamin D or a placebo for a year. Researchers will mea…

This study looks at whether testosterone replacement therapy (TRT) is safe and beneficial for men with low-risk prostate cancer who are on active surveillance (watchful waiting). Many men with low testosterone avoid TRT due to fears it might worsen their cancer, but this trial ai…

This trial tests a procedure called TULSA that uses MRI-guided sound waves to heat and destroy prostate cancer cells. It is for men aged 45-80 with low to intermediate grade prostate cancer that hasn't spread. The goal is to see if this approach can control the cancer while helpi…

This study tests whether adding a drug called apalutamide to standard hormone therapy and radiation can keep prostate cancer from spreading in people whose cancer was found in lymph nodes after prostate removal surgery. About 586 participants will be randomly assigned to get eith…

This study tests whether a new type of PET/MRI scan can accurately detect if prostate cancer has spread to nearby lymph nodes. About 50 men with high-risk prostate cancer who are scheduled for prostate removal surgery will receive this scan beforehand. The goal is to see if the s…

This study tests a new way to deliver radiation for prostate cancer that hasn't spread. By using real-time tracking to adjust the beam as the prostate moves, doctors hope to reduce urinary and bowel side effects. The study will enroll 80 men with early-stage prostate cancer to se…

This study compares two ways of giving stereotactic body radiation therapy (SBRT) for prostate cancer that hasn't spread. In standard SBRT, the radiation plan is fixed. In the new approach, doctors use daily MRI or CT scans to adjust the plan to match the patient's anatomy that d…

This study tests whether a newer, shorter radiation method (adaptive therapy, 2 treatments) causes fewer side effects and maintains quality of life compared to the standard 5-treatment approach for men with localized prostate cancer. About 144 participants will be randomly assign…

This study tests a special tissue wrap placed on the nerves during prostate removal surgery for men with localized prostate cancer. The wrap aims to reduce common side effects like erectile dysfunction and urine leakage. About 25 men will take part to see if the wrap is safe and …