SJOGREN'S SYNDROME

This early-phase trial tested the safety of tofacitinib (Xeljanz), an oral drug used for rheumatoid arthritis, in 23 adults with mild-to-moderate Sjogren's syndrome. Participants took the drug or a placebo daily for 168 days. Researchers monitored side effects and disease activit…

This study tests a new drug called dazodalibep in 651 people with Sjögren's syndrome who have moderate-to-severe disease activity. The goal is to see if the drug can reduce overall disease activity and improve symptoms like dryness. Participants receive either the drug or a place…

This early-stage study tests a new treatment called RD06-04, which uses a patient's own immune cells modified to target and destroy faulty immune cells. The goal is to see if it is safe and can help control active autoimmune diseases like lupus, scleroderma, and Sjogren's syndrom…

This study looks at whether the Shingrix vaccine is safe and effective for preventing shingles in people with autoimmune rheumatic diseases like rheumatoid arthritis and lupus. About 2,000 patients will receive the vaccine or a placebo, and researchers will monitor for disease fl…

This study looks at whether helping people with inflammatory arthritis address social needs—like food, housing, or transportation—can reduce missed doctor visits. About 100 adults with conditions like rheumatoid arthritis or lupus who have missed appointments in the past year wil…

This study looks at whether changes in gut bacteria can affect Sjögren's syndrome, an autoimmune disease causing dry eyes, dry mouth, and fatigue. Researchers will measure blood markers of gut leakage in 50 adults with Sjögren's to see if these markers change when disease activit…

This study looks at immune system markers in the saliva and blood of 80 people with primary Sjögren's syndrome, a chronic disease causing dry eyes and mouth. Researchers will check for antibodies that may block a key enzyme and see how gum disease affects symptoms. The goal is to…