SJOGREN'S SYNDROME

This study is testing whether tofacitinib, a drug already approved for rheumatoid arthritis, is safe for people with Sjogren's disease. Sixty adults with mild-to-moderate Sjogren's will take the pill twice daily for 28 weeks. Researchers will track side effects and measure change…

This early-phase trial is testing a personalized immune cell therapy called CD19 CAR-T in 15 people with severe autoimmune diseases like lupus and scleroderma that haven't responded to standard treatments. The therapy aims to temporarily deplete certain immune cells to calm the o…

This early-stage study tests a new cell therapy called YTS109 in 18 adults aged 18-65 with autoimmune diseases like lupus and Sjogren's syndrome that have not responded to standard treatments. Participants receive a single infusion of the cells, and researchers monitor safety and…

This early-stage study is testing a new treatment using a patient's own immune cells, modified to target and attack faulty immune cells that cause autoimmune diseases like lupus, scleroderma, and Sjogren's syndrome. The goal is to see if this approach is safe and can control dise…

This early study tests a new drug called CLN-978 in 36 people with active, moderate to severe Sjogren's disease. The drug is given as a shot under the skin. The main goal is to check safety and side effects, and to see how the drug affects immune cells. This is not a cure, but ai…

This study tests an online program that teaches diet and self-care habits to adults with rheumatoid arthritis, lupus, Sjogren's syndrome, mixed connective tissue disease, or psoriatic arthritis. Researchers want to see if the program reduces fatigue and improves quality of life. …

This study is trying to understand why some people who take Plaquenil (a drug for lupus and rheumatoid arthritis) develop damage to their retina, while others don't. Researchers will compare the genes of people who have had this eye damage with those who haven't, using blood samp…

This study follows 300 people with Sjogren's disease (or symptoms) over time to learn how the condition starts and progresses. Participants undergo exams, saliva and tear tests, and questionnaires during several visits. No treatment is given; the goal is to gather data and sample…

This registry enrolls pregnant women or those planning pregnancy who have autoimmune diseases like lupus or rheumatoid arthritis. Researchers at Duke University will track health data to find ways to improve outcomes for mothers and babies. The goal is to better understand risk f…

This study is building a large registry and biorepository of 5,000 adults with various rheumatic diseases like rheumatoid arthritis, lupus, and scleroderma. Researchers at Yale University will collect medical data and biological samples over time to better understand these condit…

This study looks at how natural cannabis compounds (phytocannabinoids) affect immune cells from 100 people with chronic inflammatory diseases like rheumatoid arthritis, lupus, and Crohn's disease. Researchers will take a blood sample and expose the cells to different cannabis ext…

This study looks at whether a generative AI tool can help doctors find complications of rheumatoid arthritis (RA), such as lung disease or heart problems. Researchers will review past patient records and also observe how doctors use AI suggestions in real time. About 100 RA patie…

This study aims to learn more about diseases that affect the salivary glands, which produce saliva. Researchers will collect medical information, blood, saliva, and tissue samples from people with these conditions, their relatives, and healthy volunteers. The goal is to better un…

This study is testing whether a special PET scan (FAPI PET) can show inflammation in people with Sjögren's syndrome, an autoimmune disease that causes dryness. Researchers will compare the scan results with blood tests and also look at scans from tumor patients to see differences…