SCHIZOPHRENIA DISORDERS

This early-phase study tests whether a single shot of a long-acting form of the drug brexpiprazole is safe and tolerable in healthy volunteers and people with schizophrenia. Researchers will monitor side effects, vital signs, and lab results over time. The goal is to gather initi…

This study tests whether tirzepatide, a drug approved for diabetes and obesity, can help people with both schizophrenia and alcohol use disorder drink less. About 108 participants will receive either tirzepatide or a placebo for 16 weeks, and researchers will track changes in hea…

This study tests whether adding a trauma-focused therapy called EMDR to usual care can help reduce trauma symptoms in people with schizophrenia spectrum disorders. About 187 participants aged 16 and older who have experienced a distressing trauma will receive up to 26 EMDR sessio…

This study tests whether learning music—through rhythm, singing, and body movement—can improve attention and thinking in people with schizophrenia. About 120 adults with stable schizophrenia will take part in a 6-month music-based cognitive training program. The goal is to see if…

This study will look at 100 adults admitted to NHS mental health wards to learn about their physical and mental health. Researchers will review medical notes, do physical exams, and use questionnaires to measure conditions like depression, mania, and anxiety. The goal is to bette…

This study looks at how people with schizophrenia learn and update their beliefs after treatment for persecutory delusions. Researchers will use therapy, brain scans (MRI), and computer tasks to see if treatment changes how the brain handles uncertainty. The goal is to better und…

This study is testing a program called iTEST for people with schizophrenia or related disorders. The program combines daily brain-training exercises on a mobile device with coaching to help participants accurately judge their own abilities. Researchers want to see if this improve…

This study will collect genetic information and health records from 50,000 people with serious mental illnesses like bipolar disorder, schizophrenia, major depression, and dementia. Researchers will analyze this data to find better ways to diagnose and treat these conditions. Par…

This study looks at how the brain processes visual information in people with schizophrenia, bipolar disorder, or schizoaffective disorder. Researchers will use EEG to measure brain activity while participants view images. The goal is to find early markers of psychosis that could…

This study looks at whether learning to play a pretend musical instrument can help repair brain connections in people with schizophrenia. The goal is to see if this training can improve how fast the brain processes information. Researchers will use brain scans to measure changes …

This study looks at whether diroximel fumarate, a drug already used for multiple sclerosis, can increase glutathione—a key antioxidant—in the brains of people with schizophrenia. Thirty adults with stable schizophrenia will take the drug for two weeks, then either continue it or …

This study explores how a non-invasive brain stimulation technique called theta burst stimulation (TMS) affects brain activity in people with schizophrenia. Researchers aim to understand if they can safely target the hippocampus, a brain region linked to symptoms like delusions a…