SARCOMA, SOFT TISSUE

This phase 2 trial tests whether giving a drug called anlotinib (which cuts off tumor blood supply) along with immunotherapy (penpulimab) and radiation before surgery can improve outcomes for people with soft tissue sarcoma in the arms, legs, or trunk. The study will enroll 30 ad…

This phase 2 trial is testing the combination of two chemotherapy drugs, pemetrexed and cisplatin, in 164 adults with advanced or recurrent soft tissue sarcoma. The goal is to see if this treatment can slow tumor growth in people who have already tried standard therapies. Partici…

This study tests whether adding an experimental immunotherapy drug called retifanlimab to standard chemotherapy (gemcitabine and docetaxel) is safe and effective for people with advanced soft tissue sarcoma that cannot be removed by surgery. About 98 participants will receive the…

This study tests a new, faster radiation treatment using protons or carbon ions before surgery for a rare type of cancer called retroperitoneal soft tissue sarcoma. The goal is to see if this approach is safe and practical. About 64 adults whose tumors can be surgically removed w…

This study looks at whether adding metformin, a common diabetes medicine, to standard cancer treatment can help people with advanced soft tissue sarcoma live longer. About 50 adults whose cancer has spread or cannot be removed will take metformin along with their usual therapy. T…

This study compares two different radiation schedules given before surgery for soft tissue sarcoma. One schedule is 14 sessions over about 3 weeks, and the other is just 5 sessions over about 1 week. The goal is to see if the shorter course causes fewer wound complications after …

This study tests whether adding heat therapy to chemotherapy, radiation, and surgery is feasible for people with high-risk soft tissue sarcoma of the arms, legs, or trunk. About 24 participants will receive all treatments before surgery. The goal is to see if most patients can co…

This study tests if a single-use negative pressure wound dressing (PICO14) can reduce wound problems after surgery for limb sarcoma in patients who had radiation therapy. About 48 adults will be randomly assigned to get either the special dressing or standard gauze. The main goal…

This early-phase study tests a personalized cell therapy for people with several types of advanced cancer that have spread and express a protein called NY-ESO-1. Participants receive a single infusion of their own immune cells that have been genetically modified to recognize and …

This study looks at how well children walk after having surgery for bone or soft tissue cancer in their legs. Researchers will use 3D cameras, muscle sensors, and wearable devices to measure movement in 300 children, comparing them to healthy kids of the same age. The goal is to …

This study creates a registry to collect information from 100 adults newly diagnosed with epithelioid hemangioendothelioma (EHE), an ultra-rare sarcoma. Researchers will track patients over time to understand how the disease progresses, what factors affect outcomes, and which tre…

This registry is collecting information from up to 9,000 people in Germany with sarcoma or carcinosarcoma. Researchers will track how often different subtypes occur, how they progress, and what treatments patients receive. The goal is to better understand these rare cancers and i…

This study follows 120 adults with retroperitoneal sarcoma who need surgery that also removes part of the colon or rectum. Researchers will compare different surgical techniques and track complications and quality of life using surveys. The goal is to provide better guidance for …