SARCOMA,SOFT TISSUE

This early-stage trial tests whether a patient's own immune cells can be genetically modified to recognize and attack their cancer. The study is for adults with advanced cancers that have spread and express a specific marker called NY-ESO-1. Researchers will first find the safest…

This study is testing whether adding an experimental immunotherapy drug called retifanlimab to standard chemotherapy (gemcitabine and docetaxel) is safe and more effective for treating advanced soft tissue sarcoma. The goal is to see if the combination can better control the canc…

This study is testing two types of advanced radiation therapy (protons or carbon ions) given before surgery for abdominal soft tissue sarcoma. The main goal is to see if these treatments are safe and cause fewer severe side effects to nearby organs compared to standard radiation.…

This study is testing if a special single-use wound dressing can help prevent healing problems after surgery to remove limb sarcoma (a type of cancer). The dressing uses gentle suction to help the wound close. Researchers will compare this new dressing to standard gauze bandages …

This study compares two shorter radiation schedules before surgery for soft tissue sarcoma. Patients will receive either 14 treatments over 3 weeks or just 5 treatments over 1 week before their operation. Researchers want to see if the much shorter 5-treatment approach works as w…

This trial is testing whether a new combination treatment approach is practical for patients with high-risk soft tissue sarcomas. It combines chemotherapy with targeted heat therapy, followed by radiation and surgery, to try to improve survival. The study will enroll 24 patients …

This study is testing a two-part treatment for soft tissue sarcoma in the arms, legs, or trunk before surgery. It combines a targeted form of radiation with a drug called anlotinib, aiming to shrink the tumor and make surgery more effective. The main goal is to see if this approa…

This study is testing if adding the common diabetes medication metformin to standard first-line chemotherapy can help people with advanced soft tissue sarcoma that has spread or cannot be surgically removed. About 50 adults who are starting their first treatment for this advanced…

This study is creating a large national registry to collect information about sarcoma, a rare type of cancer, and related tumors in Germany. It aims to enroll up to 9,000 adult patients to better understand how these cancers are currently treated and what outcomes patients experi…

This study aims to understand how different surgical techniques for removing complex abdominal tumors affect patients' recovery and quality of life. It will observe 120 patients who have had major surgery for retroperitoneal sarcoma, tracking complications and bowel function. The…