SARCOMA,SOFT TISSUE

This study tests a new type of radiation (protons or carbon ions) given before surgery for a rare cancer called retroperitoneal sarcoma. The goal is to see if this approach is safe and practical. About 64 adults with resectable tumors will participate.

This study tests whether adding metformin, a common diabetes medicine, to standard cancer therapy helps people with advanced soft tissue sarcoma live longer. About 50 adults whose cancer has spread or cannot be removed will receive metformin alongside their first-line treatment. …

This study tests whether adding an experimental immunotherapy drug called retifanlimab to standard chemotherapy (gemcitabine and docetaxel) can help control advanced soft tissue sarcoma that has spread or cannot be removed by surgery. About 98 adults with this type of cancer will…

This study tests whether a single-use negative pressure wound dressing (PICO14) can reduce wound complications after surgery for soft tissue sarcoma of the limbs in patients who had radiation therapy. About 48 adults will be randomly assigned to receive either the special dressin…

This study tests whether adding heat therapy (hyperthermia) to chemotherapy before surgery and radiation is feasible for people with high-risk soft tissue sarcoma in the arms, legs, or trunk. The goal is to see if patients can complete all planned treatments. About 24 adults will…

This study is for adults with soft tissue sarcoma who need radiation before surgery. It compares a standard 14-session radiation schedule to a shorter 5-session schedule. The goal is to see if the shorter course leads to similar wound healing and cancer control, while being more …

This study tests a combination of two chemotherapy drugs, pemetrexed and cisplatin, in people with advanced or recurrent soft tissue sarcoma that has not responded to prior treatments. The goal is to see if this combination can slow tumor growth and improve outcomes. About 164 ad…

This study tests whether giving a drug called anlotinib along with radiation therapy before surgery can help people with soft tissue sarcoma in the arms, legs, or trunk. About 30 adults will receive this combination to see if it reduces major wound problems after surgery and impr…

This early-stage trial tests a treatment where a patient's own immune cells are modified in a lab to better recognize and attack cancer cells that have a marker called NY-ESO-1. The study includes people with advanced cancers like sarcoma, melanoma, breast, lung, bladder, and ova…

This study looks at different surgical methods for removing colorectal parts during treatment for retroperitoneal sarcoma, a rare cancer in the abdomen. Researchers will track complications and use surveys to measure patients' quality of life after surgery. The goal is to help su…

This study is creating a registry of 100 adults newly diagnosed with epithelioid hemangioendothelioma (EHE), a very rare type of sarcoma. Researchers will collect information over time to better understand how the disease behaves, what factors affect outcomes, and which treatment…

This study looks at how serious walking problems are for children with bone or soft tissue cancer who have had orthopedic surgery. Researchers will use 3D cameras and sensors to track their movement over time and compare it to healthy children. The goal is to understand what caus…

This study is a large registry that will collect information from up to 9,000 people in Germany who have been diagnosed with sarcoma or carcinosarcoma. The goal is to gather data on how often different types of sarcoma occur, their outcomes, and how they are treated. No new treat…