RELAPSING - REMITTING MULTIPLE SCLEROSIS

This completed Phase 3 trial tested the oral drug dimethyl fumarate (Tecfidera) against an injected interferon in 156 children aged 10 to 17 with relapsing-remitting multiple sclerosis. The main goal was to see if the drug could prevent new brain lesions and control the disease s…

This study looked at whether it is safe for people with multiple sclerosis to receive their natalizumab (Tysabri) infusions at home instead of at a hospital. Researchers compared serious side effects, quality of life, and costs over one year in 295 patients. The goal was to see i…

This study tested a monthly injection of ofatumumab in 180 people with very early relapsing-remitting multiple sclerosis (MS). The goal was to see if the drug could stop all signs of disease activity—like relapses, disability worsening, and new brain lesions—over 18 months. Resea…

This study looked at how ocrelizumab, a standard MS medication, changes brain inflammation in 22 people with multiple sclerosis. Researchers used special PET and MRI scans to measure inflammation before and after one year of treatment. The goal was to see if the drug reduces harm…

This completed Phase 2 trial tested whether combining two common drugs—metformin (for diabetes) and clemastine (an antihistamine)—can help repair the protective lining of nerve cells in people with relapsing-remitting multiple sclerosis. The 70 participants continued their usual …

This study tested an experimental oral drug called PIPE-307 in 182 adults with relapsing-remitting multiple sclerosis (MS). Participants took either a low or high dose of PIPE-307 or a placebo daily for about 30 weeks, alongside their usual MS medication. The goal was to see if t…

This study tested whether a person's own stem cells (called HB-adMSCs) could improve quality of life for people with multiple sclerosis. Twenty-four adults with relapsing-remitting MS received either the stem cells or a placebo through six infusions over a year, while continuing …

This study compares two gentle exercise programs—tai chi and square stepping—in women with multiple sclerosis. Researchers want to see if these activities improve knee joint awareness, leg strength, and fatigue. About 39 women aged 20-45 with mild MS will participate, helping to …

This study tested whether a home-based program combining motor imagery (mentally practicing movements) and action observation (watching videos of movements) could help people with multiple sclerosis improve balance, walking, and fatigue. Twenty-nine adults with MS participated in…

This study tested whether acupressure, a technique where pressure is applied to specific points on the body, can help people with multiple sclerosis (MS) manage pain, fatigue, and sleep problems. Researchers enrolled 90 adults with relapsing-remitting MS who had moderate to sever…

This study looked at whether a water-based exercise program (hydrotherapy) could help improve balance and reduce fatigue in people with multiple sclerosis. 26 adults with relapsing-remitting MS took part in 16 hydrotherapy sessions. Researchers measured changes using the Berg Bal…

This study tested whether special leg exercises could improve balance, walking, and fatigue in people with multiple sclerosis (MS). Twenty-six adults with MS did either the special exercises or standard leg strengthening for six weeks. The goal was to see if these exercises could…

This study tested whether a combination of mild brain stimulation (tDCS) and computer-based cognitive training could improve memory, attention, and brain flexibility in people with multiple sclerosis. Forty-five adults with relapsing-remitting MS took part. The goal was to see if…

This study looked at whether asking people with multiple sclerosis (MS) to do two things at once — like walking while thinking — can uncover balance problems that standard tests miss. Researchers studied 24 people with mild MS and low disability. The goal was to see if this dual-…

This study followed 115 people with relapsing-remitting multiple sclerosis for up to 5 years to see if early damage to the spinal cord could predict later walking difficulties. Researchers used MRI scans and walking tests to track changes. The goal was to better understand how ea…

This study used advanced MRI scans to look at energy use in the brains of 40 people with multiple sclerosis and 15 healthy volunteers. The goal was to see if energy problems in brain cells can predict nerve damage over two years. Researchers hope this will help understand how MS …

This study tested whether smartphone communication and a special questionnaire could help confirm MS relapses without requiring an in-person visit. Researchers worked with 150 people with relapsing-remitting MS to see if this approach improves patient satisfaction and care. The g…

This study looked at how nerve cells in the eye are lost in people with multiple sclerosis (MS) even when there is no active inflammation. Researchers followed 64 adults with relapsing-remitting MS who were already part of a larger study. By using special eye scans over time, the…

This study used brain scans to understand why some people with multiple sclerosis have trouble with social thinking, like reading emotions or intentions. Researchers compared 35 MS patients to healthy volunteers using MRI while they performed social tasks. The goal was to see whi…

This study looked at whether a multiple sclerosis (MS) drug called Ofatumumab (Kesimpta) can make immune cells less toxic to brain cells. Researchers took blood samples from 40 people with relapsing-remitting MS before and after 6 months of treatment. They tested if the chemicals…

This study used a special eye camera (adaptive optics) to look at blood vessel inflammation in the retina of 50 people with multiple sclerosis (MS) and healthy volunteers. The goal was to see if this inflammation differs between MS types and could serve as an early marker of dise…

This study looked at how the COVID-19 pandemic changed the way people with multiple sclerosis (MS) reported and managed their relapses. Researchers compared 51 patients who had a relapse during the first wave of the pandemic (April–June 2020) with those who had a relapse during t…

This completed study involved 15 people with relapsing-remitting multiple sclerosis who were already taking alemtuzumab. Researchers measured anti-drug antibodies in their blood over 24 months to see if these antibodies affect treatment or cause infusion reactions. The goal was t…

This study compared traditional pencil-and-paper tests with virtual reality tasks (like driving simulations and a virtual supermarket) to assess attention and executive function in 60 people with relapsing-remitting multiple sclerosis. The goal was to see if VR can better detect …

This study looked at fatigue in 60 people with multiple sclerosis (MS) to compare how patients describe their tiredness with results from physical and cognitive tests. Researchers used questionnaires, walking tests, grip strength, and balance assessments to get a fuller picture o…

This study compared 101 people with multiple sclerosis to healthy volunteers to see if they can recognize positive emotions like joy and enthusiasm. Participants completed questionnaires and tests to evaluate their ability to identify emotions from faces and voices. The goal was …

This completed observational study followed 367 people with relapsing-remitting or active secondary progressive multiple sclerosis who were taking Kesimpta for the first time. Researchers tracked side effects and how well the drug worked in everyday use. The goal was to gather re…

This study reviewed medical records of 800 multiple sclerosis patients to see if gender, race, or socioeconomic status affected how quickly they started Ocrelizumab or how well it worked. Researchers looked at relapse rates and MRI changes over 12 to 24 months. The goal was to id…

This completed study measured two proteins in the blood—neurofilament light chain and GFAP—that can signal nerve damage. Researchers compared 15 people with atypical MS, 30 with typical MS, and 15 healthy controls to see if these markers differ. The goal was to better understand …

This study looked at how different types of exercise affect the brain and body in people with multiple sclerosis (MS). Twelve participants tried traditional aerobic exercise, virtual reality (VR) aerobic exercise (using the game Beat Saber), and standard exercises. Researchers me…

This completed study looked at how depression affects the ability to recognize emotions in people with multiple sclerosis (MS). Researchers used EEG, heart rate monitoring, and questionnaires to compare emotion recognition in MS patients with and without depression, as well as he…