RECURRENT MALIGNANT NEOPLASM
Clinical trials for RECURRENT MALIGNANT NEOPLASM explained in plain language.
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New drug cocktail trial aims to tame tough tumors
Disease control OngoingThis early-phase trial tests the safety and best doses of two drugs (bevacizumab and temsirolimus) given alone or with other medicines (valproic acid or cetuximab) in people with advanced cancer or certain non-cancerous diseases that are hard to treat. The goal is to find the hig…
Matched conditions: RECURRENT MALIGNANT NEOPLASM
Phase: PHASE1 • Sponsor: M.D. Anderson Cancer Center • Aim: Disease control
Last updated May 14, 2026 12:06 UTC
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New hope for tough cancers: drug targets BRCA mutations
Disease control OngoingThis study tests a drug called talazoparib in people with advanced cancers that have not responded to standard treatments. The drug works by blocking an enzyme that helps cancer cells survive, especially in tumors with changes in the BRCA genes or related DNA repair genes. The go…
Matched conditions: RECURRENT MALIGNANT NEOPLASM
Phase: PHASE2 • Sponsor: M.D. Anderson Cancer Center • Aim: Disease control
Last updated May 01, 2026 15:59 UTC
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Fatigue-Busting combo for cancer patients shows promise in new study
Symptom relief OngoingThis study looks at whether a medication called methylphenidate (often used for ADHD) combined with physical activity can reduce severe tiredness in people with advanced cancer who are on immunotherapy. About 212 participants will be randomly assigned to receive either the drug o…
Matched conditions: RECURRENT MALIGNANT NEOPLASM
Phase: PHASE3 • Sponsor: M.D. Anderson Cancer Center • Aim: Symptom relief
Last updated May 17, 2026 05:08 UTC
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Can a common antipsychotic ease delirium in dying cancer patients?
Symptom relief OngoingThis study looks at whether haloperidol, given alone or with chlorpromazine, can safely reduce severe agitation and confusion (delirium) in people with advanced cancer who are in a palliative care unit. About 70 participants will receive the drugs and be monitored for 24 hours. T…
Matched conditions: RECURRENT MALIGNANT NEOPLASM
Phase: PHASE2, PHASE3 • Sponsor: M.D. Anderson Cancer Center • Aim: Symptom relief
Last updated May 17, 2026 05:06 UTC
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Exercise plus steroid shows promise for cancer fatigue
Symptom relief OngoingThis study tests whether adding a short course of the steroid dexamethasone to a physical activity program can reduce severe fatigue in people with advanced cancer. About 90 participants will be randomly assigned to receive either a high or low dose of dexamethasone along with ex…
Matched conditions: RECURRENT MALIGNANT NEOPLASM
Phase: PHASE2, PHASE3 • Sponsor: M.D. Anderson Cancer Center • Aim: Symptom relief
Last updated May 17, 2026 05:05 UTC
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New hope for calming agitated delirium in dying cancer patients
Symptom relief OngoingThis study looks at how well two drugs, haloperidol and lorazepam, can control severe agitation and confusion (delirium) in advanced cancer patients receiving palliative care. About 110 patients whose delirium did not improve with low-dose haloperidol will be given different drug…
Matched conditions: RECURRENT MALIGNANT NEOPLASM
Phase: PHASE2, PHASE3 • Sponsor: M.D. Anderson Cancer Center • Aim: Symptom relief
Last updated May 15, 2026 12:03 UTC
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Gene test vs. standard care: which works better for advanced cancer?
Knowledge-focused OngoingThis study looks at whether analyzing the genetic changes in a patient's tumor can help doctors pick a more effective targeted therapy for metastatic cancer. Over 1,300 patients with cancer that has spread are randomly assigned to receive either a treatment chosen based on their …
Matched conditions: RECURRENT MALIGNANT NEOPLASM
Phase: PHASE2 • Sponsor: M.D. Anderson Cancer Center • Aim: Knowledge-focused
Last updated May 17, 2026 05:04 UTC
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Cancer's hidden cost: study reveals financial burden on patients
Knowledge-focused OngoingThis study looks at how serious money problems are for people with advanced cancer. Cancer care can be very expensive, and the stress from debt and high costs may make physical symptoms and quality of life worse. About 141 patients will fill out a short survey to measure their fi…
Matched conditions: RECURRENT MALIGNANT NEOPLASM
Sponsor: M.D. Anderson Cancer Center • Aim: Knowledge-focused
Last updated May 11, 2026 20:48 UTC