RECURRENT GLIOBLASTOMA
Clinical trials for RECURRENT GLIOBLASTOMA explained in plain language.
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Brain tumor chemo delivered by pump shows promise in tiny safety trial
Disease control CompletedThis early-phase study tested whether pumping the chemotherapy drug topotecan directly into the brain is safe for people with recurrent high-grade gliomas (aggressive brain tumors). Only 5 patients took part, and the main goal was to find a safe dose. The drug was delivered conti…
Matched conditions: RECURRENT GLIOBLASTOMA
Phase: PHASE1 • Sponsor: Columbia University • Aim: Disease control
Last updated Jun 27, 2026 12:23 UTC
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Sound waves + radiation: new hope for tough brain tumors?
Disease control CompletedThis small pilot study tested whether combining focused ultrasound with a second round of radiation is safe for people with recurrent glioblastoma, an aggressive brain cancer. Seven adults who had already tried standard treatments received the combination therapy. The goal was to…
Matched conditions: RECURRENT GLIOBLASTOMA
Phase: NA • Sponsor: NaviFUS Corporation • Aim: Disease control
Last updated Jun 27, 2026 12:06 UTC
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Sound waves open Brain's shield to attack deadly tumors
Disease control CompletedThis study tested a device that uses sound waves and tiny bubbles to temporarily open the blood-brain barrier in 28 people with recurrent glioblastoma, a type of brain cancer. The goal was to see if it is safe and feasible to let the chemotherapy drug carboplatin reach the tumor …
Matched conditions: RECURRENT GLIOBLASTOMA
Phase: PHASE1, PHASE2 • Sponsor: InSightec • Aim: Disease control
Last updated Jun 27, 2026 11:03 UTC
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Tailored tumor attack: can custom drug cocktails beat recurrent glioblastoma?
Disease control CompletedThis pilot study tested whether it's possible to quickly create and start a personalized drug combination for each patient with recurrent glioblastoma, a serious brain cancer. Researchers used genetic testing on tumor tissue to pick drugs that target specific mutations. The study…
Matched conditions: RECURRENT GLIOBLASTOMA
Phase: PHASE1 • Sponsor: Jennifer Clarke • Aim: Disease control
Last updated Jun 27, 2026 09:05 UTC
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Sound waves open brain's shield to attack deadly tumors
Disease control CompletedThis early-phase study tested whether a focused ultrasound device can safely open the blood-brain barrier in 13 adults with recurrent glioblastoma, a severe brain cancer. The goal was to let the chemotherapy drug carboplatin reach the tumor more effectively. The study focused on …
Matched conditions: RECURRENT GLIOBLASTOMA
Phase: PHASE1, PHASE2 • Sponsor: InSightec • Aim: Disease control
Last updated Jun 27, 2026 08:13 UTC
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New drug combo targets recurrent brain tumors in early trial
Disease control CompletedThis phase 1 trial tested a combination of two drugs, ASP8374 and cemiplimab (Libtayo), in 14 people with recurrent malignant glioma, a type of brain cancer. The study had two parts: first, finding the safest dose of ASP8374 when given with cemiplimab, and second, checking how th…
Matched conditions: RECURRENT GLIOBLASTOMA
Phase: PHASE1 • Sponsor: Dana-Farber Cancer Institute • Aim: Disease control
Last updated Jun 27, 2026 07:55 UTC
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New dye could sharpen PET scans for recurrent brain cancer
Diagnosis CompletedThis study tested whether a special dye called fluoroethyltyrosine (FET) can improve PET scans for detecting brain tumors that have come back. 143 people with suspected recurrent brain tumors received an injection of FET before their PET scan. The goal was to see if FET-PET could…
Matched conditions: RECURRENT GLIOBLASTOMA
Phase: PHASE2 • Sponsor: Thomas Hope • Aim: Diagnosis
Last updated Jun 27, 2026 11:01 UTC
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Gene mapping could open new doors for brain tumor patients
Knowledge-focused CompletedThis study looked at whether whole genome sequencing of recurrent glioblastoma tumors can uncover more targeted treatment options. Researchers analyzed tumor samples from 164 patients who had surgery for their first recurrence. The goal was to see if this detailed genetic testing…
Matched conditions: RECURRENT GLIOBLASTOMA
Phase: NA • Sponsor: UMC Utrecht • Aim: Knowledge-focused
Last updated Jun 27, 2026 13:03 UTC