Sound waves open Brain's shield to attack deadly tumors
NCT ID NCT04417088
First seen Jun 25, 2026 · Last updated Jun 27, 2026 · Updated 1 time
Summary
This study tested a device that uses sound waves and tiny bubbles to temporarily open the blood-brain barrier in 28 people with recurrent glioblastoma, a type of brain cancer. The goal was to see if it is safe and feasible to let the chemotherapy drug carboplatin reach the tumor more effectively. The trial combined the device procedure with carboplatin infusion and monitored side effects and brain imaging.
What this could mean
Our plain-language read of the trial. This is informational only — not medical advice or a prediction.
Active substance
Carboplatin (chemotherapy) and Exablate Neuro device with microbubbles to open the blood-brain barrier
What this could lead to
If it works, this could offer a new way to deliver chemotherapy directly to brain tumors, potentially improving treatment for recurrent glioblastoma.
What could go wrong
This is an early-phase study with only 28 participants, so results may not apply to everyone. The procedure carries risks like bleeding or swelling in the brain.
Disclaimer
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This is a summary of
the original study
.
Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
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Locations
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Brigham and Women's Hospital
Boston, Massachusetts, 02115, United States
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Cleveland Clinic
Cleveland, Ohio, 44195, United States
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Stanford University
Palo Alto, California, 94304, United States
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University of Maryland
Baltimore, Maryland, 21201, United States