Sound waves open brain barrier to attack deadly tumors

NCT ID NCT04417088

First seen Jan 22, 2026 · Last updated May 13, 2026 · Updated 19 times

Summary

This study tested whether a special ultrasound device can safely and temporarily open the blood-brain barrier in people with recurrent glioblastoma, a type of brain cancer. The goal was to let the chemotherapy drug carboplatin reach the tumor more effectively. 28 participants were enrolled to check safety and see if the barrier opening worked on MRI scans.

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Contacts and locations

Locations

  • Brigham and Women's Hospital

    Boston, Massachusetts, 02115, United States

  • Cleveland Clinic

    Cleveland, Ohio, 44195, United States

  • Stanford University

    Palo Alto, California, 94304, United States

  • University of Maryland

    Baltimore, Maryland, 21201, United States

Conditions

Explore the condition pages connected to this study.