Sound waves open brain's shield to attack deadly tumors

NCT ID NCT04440358

First seen Jan 24, 2026 · Last updated May 16, 2026 · Updated 14 times

Summary

This early-phase study tested whether a focused ultrasound device can safely open the blood-brain barrier in 13 patients with recurrent glioblastoma, a severe brain cancer. The goal was to let the chemotherapy drug carboplatin reach the tumor more effectively. The study focused on safety and whether the barrier could be opened, not on curing the disease.

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Contacts and locations

Locations

  • Fondazione IRCCS Neurologico Carlo Besta

    Milan, 20133, Italy

  • Sunnybrook Health Sciences Centre

    Toronto, Ontario, M4N 3M5, Canada

  • Yonsei University Medical Center

    Seoul, 120-752, South Korea

Conditions

Explore the condition pages connected to this study.