Sound waves open brain's shield to attack deadly tumors

NCT ID NCT04440358

First seen Jun 27, 2026 ยท Last updated Jun 27, 2026

Summary

This early-phase study tested whether a focused ultrasound device can safely open the blood-brain barrier in 13 adults with recurrent glioblastoma, a severe brain cancer. The goal was to let the chemotherapy drug carboplatin reach the tumor more effectively. The study focused on safety and whether the barrier could be opened, not on curing the disease.

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Conditions

The condition(s) this trial relates to.

glioblastoma

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Contacts and locations

Locations

  • Fondazione IRCCS Neurologico Carlo Besta

    Milan, 20133, Italy

  • Sunnybrook Health Sciences Centre

    Toronto, Ontario, M4N 3M5, Canada

  • Yonsei University Medical Center

    Seoul, 120-752, South Korea