RECTAL NEOPLASMS
Clinical trials for RECTAL NEOPLASMS explained in plain language.
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Immunotherapy combo shows promise in rectal cancer after standard treatment
Disease control OngoingThis study tests whether adding two immunotherapy drugs (atezolizumab and tiragolumab) after standard chemoradiation can help eliminate tumors in people with locally advanced rectal cancer. About 58 participants will receive either the drug combination or atezolizumab alone befor…
Matched conditions: RECTAL NEOPLASMS
Phase: PHASE2 • Sponsor: Hoffmann-La Roche • Aim: Disease control
Last updated Jun 27, 2026 12:23 UTC
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Robot-Assisted surgery aims to improve rectal tumor removal
Disease control OngoingThis study tests a new robotic surgery method for removing rectal tumors. The approach uses a single-port robot to improve flexibility and visibility during the operation. Researchers will study 20 patients with benign or early-stage rectal tumors to see if the procedure is safe …
Matched conditions: RECTAL NEOPLASMS
Phase: NA • Sponsor: Jeng-Fu You • Aim: Disease control
Last updated Jun 27, 2026 12:09 UTC
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New combo therapy aims to save rectums from surgery
Disease control OngoingThis study tests whether giving either short-course radiation or long-course chemoradiation, followed by a strong chemotherapy cocktail (mFOLFOXIRI), can shrink low rectal tumors enough to avoid radical surgery. About 66 adults with stage T2-4a rectal cancer whose tumor is within…
Matched conditions: RECTAL NEOPLASMS
Phase: PHASE2 • Sponsor: Pei-Rong Ding • Aim: Disease control
Last updated Jun 27, 2026 12:06 UTC
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New Stitch-Free staple technique aims to cut leak risk in rectal cancer surgery
Disease control ENROLLING_BY_INVITATIONThis trial tests a modified stapling technique (MST) against the standard method in 450 adults having minimally invasive rectal cancer surgery. The goal is to see if MST reduces the chance of anastomotic leaks, a serious complication. Participants will be randomly assigned to one…
Matched conditions: RECTAL NEOPLASMS
Phase: NA • Sponsor: Korea University Anam Hospital • Aim: Disease control
Last updated Jun 27, 2026 09:00 UTC
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Extra stitches may cut leak risk after rectal cancer surgery
Disease control ENROLLING_BY_INVITATIONThis study tests whether adding extra stitches around the surgical connection in laparoscopic low rectal cancer surgery can reduce the risk of dangerous leaks. About 300 adults with low rectal cancer will be assigned to either standard surgery or surgery with reinforced stitching…
Matched conditions: RECTAL NEOPLASMS
Phase: NA • Sponsor: Shanghai 10th People's Hospital • Aim: Disease control
Last updated Jun 27, 2026 08:11 UTC
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New radiation approach may help rectal cancer patients avoid surgery
Disease control OngoingThis study tests whether a special type of internal radiation (contact X-ray brachytherapy) given after standard chemoradiation can help more people with early rectal cancer keep their rectum, compared to standard external beam radiation. About 148 adults with small, early-stage …
Matched conditions: RECTAL NEOPLASMS
Phase: PHASE3 • Sponsor: Centre Antoine Lacassagne • Aim: Disease control
Last updated Jun 27, 2026 07:52 UTC
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Could a plant extract make rectal cancer treatment easier to tolerate?
Symptom relief OngoingThis study tests whether adding chlorophyllin, a natural plant extract, to standard chemoradiation can reduce side effects like diarrhea, bladder irritation, and low blood counts in people with locally advanced rectal cancer. About 76 adults will receive either chlorophyllin or a…
Matched conditions: RECTAL NEOPLASMS
Phase: PHASE2 • Sponsor: Tata Memorial Centre • Aim: Symptom relief
Last updated Jun 27, 2026 07:51 UTC
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Blood test could spot returning colon cancer months before scans
Knowledge-focused OngoingThis study tests whether a simple blood test that looks for tumor DNA can detect colorectal cancer coming back earlier than standard CT scans. About 359 people who had surgery for stage II or III colorectal cancer will be randomly assigned to either the blood test plus frequent P…
Matched conditions: RECTAL NEOPLASMS
Phase: NA • Sponsor: Claus Lindbjerg Andersen • Aim: Knowledge-focused
Last updated Jun 27, 2026 12:24 UTC