PURE AUTONOMIC FAILURE
Clinical trials for PURE AUTONOMIC FAILURE explained in plain language.
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Warm belly, cooler blood pressure? nighttime heat test for rare disorder
Disease control Recruiting nowThis study is testing if applying gentle, controlled heat to the abdomen at night can safely lower high blood pressure in people with autonomic failure, a rare nerve disorder. Researchers will compare the effects of real heat versus a sham (fake) treatment in 20 participants. The…
Matched conditions: PURE AUTONOMIC FAILURE
Phase: NA • Sponsor: Vanderbilt University Medical Center • Aim: Disease control
Last updated Mar 23, 2026 15:14 UTC
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Abdominal binder vs medication: which better controls dangerous blood pressure drops?
Symptom relief Recruiting nowThis study compares two common treatments for low blood pressure when standing up in people with autonomic nervous system disorders. Researchers will test whether a medication called midodrine or wearing an abdominal compression binder works better to improve blood flow and reduc…
Matched conditions: PURE AUTONOMIC FAILURE
Phase: EARLY_PHASE1 • Sponsor: Vanderbilt University Medical Center • Aim: Symptom relief
Last updated Apr 01, 2026 14:41 UTC
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Inflatable belt could help patients stand without fainting
Symptom relief Recruiting nowThis study is testing a new inflatable belt worn around the abdomen to see if it safely helps people with autonomic failure stand up without getting dizzy or fainting. Researchers will compare the real belt to a 'sham' belt with very low pressure in about 31 participants. The goa…
Matched conditions: PURE AUTONOMIC FAILURE
Phase: PHASE1, PHASE2 • Sponsor: Vanderbilt University Medical Center • Aim: Symptom relief
Last updated Mar 30, 2026 14:39 UTC
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Sleep apnea device tested for dangerous blood pressure swings
Symptom relief Recruiting nowThis study is testing if a CPAP machine, commonly used for sleep apnea, can help people with autonomic failure. These patients often have dangerously high blood pressure when lying down and severe dizziness when standing up. Researchers want to see if using CPAP at night can safe…
Matched conditions: PURE AUTONOMIC FAILURE
Phase: NA • Sponsor: Vanderbilt University Medical Center • Aim: Symptom relief
Last updated Mar 09, 2026 14:25 UTC
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Brain scans could predict progression of Parkinson's and related disorders
Knowledge-focused Recruiting nowThis study uses a special brain scan to measure dopamine activity in people with autonomic failure conditions like Parkinson's disease, multiple system atrophy, and Lewy body dementia. Researchers want to see if these scans can detect early changes that might predict which patien…
Matched conditions: PURE AUTONOMIC FAILURE
Phase: PHASE1 • Sponsor: Daniel Claassen • Aim: Knowledge-focused
Last updated Mar 30, 2026 14:34 UTC
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Scientists probe how common blood pressure drugs work in rare nerve disorder
Knowledge-focused Recruiting nowThis study aims to understand how two existing medications, midodrine and droxidopa, affect blood flow in the abdomen of people with autonomic failure, a rare nerve disorder that causes severe drops in blood pressure when standing. Researchers will compare the drugs' effects on 3…
Matched conditions: PURE AUTONOMIC FAILURE
Phase: PHASE1 • Sponsor: Vanderbilt University Medical Center • Aim: Knowledge-focused
Last updated Mar 30, 2026 14:31 UTC
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Squeezing the belly to fight dizzy spells: scientists probe a simple fix
Knowledge-focused Recruiting nowThis study aims to understand how a tight abdominal binder helps people with a nerve condition that causes severe drops in blood pressure when they stand up. Researchers will compare this physical therapy to a standard medication by measuring heart and blood flow changes while pa…
Matched conditions: PURE AUTONOMIC FAILURE
Phase: PHASE1 • Sponsor: Vanderbilt University Medical Center • Aim: Knowledge-focused
Last updated Mar 23, 2026 15:18 UTC