PREDIABETIC STATE

This study tests whether taking a daily zinc supplement for one year can lower blood sugar and HbA1c levels in people with prediabetes. Researchers will compare zinc to a placebo in 200 Amish adults aged 18-80. The goal is to see if zinc can help control blood sugar and prevent t…

This study follows overweight and obese adults aged 45-65 to see if a tailored program of counseling, supervised exercise, and digital tools helps them lose weight and improve heart health over 18 months. Participants are compared to a group that only gets general written advice.…

This study tests whether applying heat pads to the legs can improve muscle health, physical function, and blood sugar control in older adults with prediabetes. Researchers will compare the effects of heat therapy to high-intensity interval training (HIIT) in 54 sedentary people a…

This study looks at time-restricted eating (a form of intermittent fasting) to see if the timing of your daily eating window affects blood sugar control. Researchers will compare three different 9-hour eating windows in 120 adults with obesity who have or are at risk for type 2 d…

This study looks at whether the time of day you exercise matters for blood sugar control in people with prediabetes. Researchers will compare morning versus late afternoon exercise in 48 adults with prediabetes. They will measure how the body stores fat and uses energy to see if …

This study looks at whether a type of talk therapy for insomnia (CBT-I) can help lower blood sugar levels in people with prediabetes. About 300 adults with both prediabetes and insomnia will either get CBT-I or general health education. The goal is to see if improving sleep can r…

This study looks at whether adding hands-on nutrition demonstrations to the standard Diabetes Prevention Program helps people at risk for prediabetes stay engaged. About 20 adults in Los Angeles will take part. The goal is to see if this approach is practical and acceptable, not …

This study looks at whether metformin, a medicine used for diabetes, can lower the risk of death, heart attacks, or strokes in veterans who have pre-diabetes and already have heart or blood vessel disease. About 7,400 participants will be followed over time. The goal is to see if…

This study looks at how the hormone insulin controls sugar and fat production in the liver. Researchers will give a single dose of the drug alpelisib (or a placebo) to healthy adults and those at risk for type 2 diabetes. Participants stay overnight twice in the hospital for infu…

This study looks at how resistance training (like lifting weights) affects fat breakdown in obese postmenopausal women who also have prediabetes. Researchers want to see if this type of exercise can improve how the body uses fat, which might help prevent type 2 diabetes. The stud…

This study aims to identify early risk factors for Alzheimer's disease by tracking memory, thinking skills, and metabolic health in 850 adults with normal cognition or mild impairment. Researchers will monitor changes in cognitive performance, brain scans, and spinal fluid biomar…

This study looks at whether a short course of the drug diazoxide can reduce how much fat the liver makes in people with obesity, insulin resistance, and a type of fatty liver disease (MASLD). About 25 adults will take either the drug or a placebo for one week, and researchers wil…