POSTOPERATIVE DELIRIUM (POD)

This study tests whether a proactive temperature management plan can reduce postoperative delirium (sudden confusion) in 174 adults undergoing cytoreductive surgery with heated chemotherapy for pseudomyxoma peritonei, a rare abdominal cancer. Participants will be randomly assigne…

This study tests whether a non-invasive brain stimulation technique called transcranial magnetic stimulation (TMS) can prevent postoperative delirium (sudden confusion) in elderly patients after urological surgery. Researchers will give TMS during surgery and monitor 220 patients…

This study tests whether a nasal spray called dexmedetomidine, taken at night, can help older adults (ages 65-90) sleep and reduce the risk of postoperative delirium after major abdominal surgery. Half of the 400 participants will receive the spray, and half will receive a placeb…

This study tests if a mild electrical pulse to the ear (vagus nerve) during heart surgery can lower the risk of postoperative delirium (sudden confusion) and reduce anxiety or depression. About 270 adults having planned heart surgery will receive either the real stimulation or a …

This study tests whether a nasal spray called dexmedetomidine can prevent confusion (delirium) in older adults after lung surgery. About 264 patients aged 65 and older will receive either the spray or a placebo before their operation. Researchers will check for signs of confusion…

This study aims to find better ways to predict early complications after heart surgery by analyzing a wide range of data—including genetics, blood tests, and even voice recordings. Researchers will follow 3,000 adult patients undergoing elective cardiac surgery, collecting sample…

This study will create a computer tool to predict which older adults are at high risk for serious problems after heart or blood vessel surgery. It will also test if special programs before and during surgery can help prevent confusion, heart issues, and death. About 1,200 people …