PEDIATRICS

This study looks at whether giving less intravenous (IV) fluid to critically ill children with traumatic injuries leads to fewer complications. Currently, there is no standard for how much fluid these children should receive. The trial will enroll 250 children aged 6 months to 15…

This study tests whether a high-energy diet helps infants with congenital heart disease grow and develop their brains better after heart surgery. Researchers will compare high-energy versus standard nutrition in 160 babies aged 0-6 months. The goal is to see if the special diet i…

This study tests a special dye called Cytalux that makes cancer cells glow under near-infrared light. Surgeons use it during lung surgery to find and remove hard-to-see tumors in teens (ages 6-17) with bone cancer that has spread to the lungs. The goal is to see if the dye helps …

This study is testing a wearable device called ViBandz that delivers gentle vibrations to help children with neurological conditions (like cerebral palsy) improve movement in their arms or legs. About 30 children, ages 6 months to 17 years, will use the device at home and give fe…

This study tests whether a topical anti-inflammatory gel works as well as oral ibuprofen for children aged 6 to 18 with recent ankle or knee injuries. The main goal is to see if a larger study is possible by checking how many families agree to join and follow the treatment plan. …

This study tests a telehealth version of Parent Child Interaction Therapy (Tele-PCIT) for 50 young children aged 2 to 6 with disruptive behavior and a history of adverse childhood experiences. Parents and children will work with a therapist via video to improve parenting skills a…

This study is translating a short, 5-minute neurological test (BRIEF-HINE) into Turkish and checking if it works well for 120 high-risk infants. These babies are at risk for conditions like cerebral palsy due to premature birth or other complications. The goal is to give doctors …

This study looks at whether a new way of scoring whole-body MRI scans can reliably measure bone inflammation in children with CRMO, a rare condition causing repeated bone pain and swelling. Researchers will compare the MRI scores from different doctors and also check if changes i…

This study tests whether a machine learning model can predict which children in the hospital will need a medication that requires a genetic test. The goal is to see if the model helps doctors order the test before giving the drug, so they can choose the right dose or a safer alte…

This study will collect information from 10,000 children admitted to intensive care units across Asia. The goal is to understand their health problems, what leads to better or worse outcomes, and to create computer tools that can predict how long they will need ICU care. No new t…

This study tests two versions of a care coordination program for children with special health care needs who are leaving the hospital. One version offers a focused amount of support, while the other provides extended help. Researchers want to see which approach reduces emergency …

This study looks at how seizures change the brain's wiring in children with drug-resistant focal epilepsy. Researchers will use special brain recordings and MRI scans to measure connections in areas where seizures start. The goal is to understand how ongoing seizures affect brain…

This study looks at how often children develop low blood sugar (hypoglycemia) when they fast before surgery. Fasting is required to prevent choking during anesthesia, but young children have less energy stored and may be at risk. Researchers will measure blood sugar in over 6,500…

This study follows healthy girls ages 8-14 and those at risk for PCOS to learn how their periods become regular in the first two years after their first period. Researchers will collect urine samples, diaries, and other health data every six months. The goal is to better understa…

This study tests whether a simple, step-by-step guide (called a linear cognitive aid) helps emergency medical teams treat children in life-threatening situations. About 80 EMS providers will use the guide during realistic practice scenarios. The goal is to see if the guide is eas…