OPIOID-RELATED DISORDERS

This study tests whether special vending machines (kiosks) placed in rural Kentucky communities can help reduce the spread of HIV, hepatitis C, and drug overdoses. About 752 adults who use drugs will use the kiosks to get clean syringes and other supplies. The goal is to see if t…

This study tests whether a smartphone app can help people receiving medication for opioid use disorder stay drug-free. The app uses location tracking to send personalized alerts when a person enters a high-risk area for relapse. Researchers will also use brain scans to understand…

This study tests whether a smartphone app can help people with opioid use disorder stay off unprescribed drugs. Participants use the app to submit videos of themselves taking saliva drug tests, get reminders and rewards, and access live support. The study lasts one year and invol…

This study tests whether a once-monthly injection of buprenorphine works as well as daily buprenorphine-naloxone pills for people with opioid use disorder living in rural areas. About 144 adults will be randomly assigned to one of the two treatments for 14 weeks. The goal is to s…

This study tests a program where pharmacists provide brief counseling and medication management to adults at risk of misusing opioids. The goal is to prevent opioid use disorder and overdose. About 350 people from 14 community pharmacies are taking part.

This study tests a treatment called cryoneurolysis, which uses cold to temporarily freeze nerves around the knee before replacement surgery. The goal is to see if it reduces pain and the need for strong painkillers (opioids) after surgery. About 100 adults scheduled for knee repl…

This study looks at whether opioid use disorder and non-fatal overdoses cause changes in a brain protein called tau. Researchers will use a special PET scan to measure tau in three groups: people with opioid use disorder who have had an overdose, those with the disorder but no ov…

This study looks at whether teaching primary care doctors about the risks of opioid painkillers and proper prescribing guidelines can reduce overprescribing. About 52 clinics are taking part. The goal is to lower the chance of addiction and misuse by helping doctors make safer ch…

This study works with overdose fatality review teams in Indiana to help them use a new data dashboard instead of just reviewing individual cases. The goal is to spot patterns and opportunities to connect people at risk with treatment. About 400 team members and leaders will take …

This study looks at whether a machine-learning tool built into electronic health records can help doctors spot patients at high risk for opioid overdose. Researchers are testing it in 13 clinics in Florida with about 674 patients. The tool sends an alert when a doctor prescribes …